Evidence map›Paper›PMID 27150382›Full record

ReviewThe lancet. Psychiatry2016

Precision psychiatry: a neural circuit taxonomy for depression and anxiety.

Leanne M Williams

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The lancet. Psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05911412 (Development of the Neuroimaging Biomarker-based Prediction Model of Anxiety-related Disorders and Novel Treatment Strategies), which is not on this map. Cited by 359 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
359citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05911412 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Development of the Neuroimaging Biomarker-based Prediction Model of Anxiety-related Disorders and Novel Treatment Strategies: Effect of Mindfulness-based Cognitive Therapy Using Neuroscience on the Brain

TypeinterventionalSponsorCHA UniversityRan2023 to 2025Enrolled64ConditionsAnxiety DepressionArmsMindfulness-based cognitive therapy using neuroscience (NMBCT)
3 · Its place in the literature

Who cites it

359 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  6. Examining fronto-limbic brain and sleep mechanisms of antidepressant effects in cognitive-behavioral therapy for insomnia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  20. Converging on control: Rethinking treatment-resistant depression through network neuroscience.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
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299 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Leanne M WilliamsDepartment of Psychiatry and Behavioral Sciences, Stanford University, CA, USA. Electronic address: leawilliams@stanford.edu.

Funding

Neural Dimensions of Threat Reactivity and Regulation for Understanding AnxietyR01MH101496 · NIMH · STANFORD UNIVERSITY · PI WILLIAMS, LEANNE · 2013 to 2016
$2.3M
NIMH NIH HHS R01 MH101496
6 · The paper itself

Abstract

Although there have been tremendous advances in the understanding of human dysfunctions in the brain circuitry for self-reflection, emotion, and cognitive control, a brain-based taxonomy for mental disease is still lacking. As a result, these advances have not been translated into actionable clinical tools, and the language of brain circuits has not been incorporated into training programmes. To address this gap, I present this synthesis of published work, with a focus on functional imaging of circuit dysfunctions across the spectrum of mood and anxiety disorders. This synthesis provides the foundation for a taxonomy of putative types of dysfunction, which cuts across traditional diagnostic boundaries for depression and anxiety and includes instead distinct types of neural circuit dysfunction that together reflect the heterogeneity of depression and anxiety. This taxonomy is suited to specifying symptoms in terms of underlying neural dysfunction at the individual level and is intended as the foundation for building mechanistic research and ultimately guiding clinical practice.

Indexed as

AnxietyBrainDepressionHumansNeural PathwaysPsychiatry

Identifiers

PMID27150382
PMCPMC4922884

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.