Evidence map›Paper›PMID 27150092›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2016

Skin Diseases in Laboratory Mice: Approaches to Drug Target Identification and Efficacy Screening.

John P Sundberg, Kathleen A Silva, Lloyd E King, C Herbert Pratt

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

John P SundbergThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609-1500, USA. john.sundberg@jax.org.
Kathleen A SilvaThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609-1500, USA.
Lloyd E KingDivision of Dermatology, Department of Medicine, Vanderbilt Medical Center, Nashville, TN, USA.
C Herbert PrattThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609-1500, USA.
Jackson Laboratory · USVanderbilt University Medical Center · US

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI William Carl Skarnes · 1985 to 2026
$61.9M
Mouse Models of Human Cancer DatabaseR01CA089713 · NCI · JACKSON LABORATORY · PI BULT, CAROL J · 2002 to 2025
$17.5M
Cpdm: Cloning a Gene That Regulates Eosinophil FunctionR01AR049288 · NIAMS · JACKSON LABORATORY · PI BOWCOCK, ANNE MARY, HOGENESCH, HARM · 2004 to 2016
$5.9M
Model Systems for PXER01AR055225 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI UITTO, JOUNI · 2008 to 2017
$3.2M
Genetics of Alopecia Areata in the C3H/HeJ MouseR01AR056635 · NIAMS · JACKSON LABORATORY · PI SUNDBERG, JOHN PAUL · 2010 to 2014
$1.9M
Discovering Novel Gene Networks for Skin DiseasesR21AR063781 · NIAMS · JACKSON LABORATORY · PI SUNDBERG, JOHN PAUL · 2013 to 2014
$422k
NCI NIH HHS P30 CA034196NCI NIH HHS R01 CA089713NIAMS NIH HHS R01 AR049288NIAMS NIH HHS R01 AR055225NIAMS NIH HHS R01 AR056635NIAMS NIH HHS R21 AR063781
6 · The paper itself

Abstract

A large variety of mouse models for human skin, hair, and nail diseases are readily available from investigators and vendors worldwide. Mouse skin is a simple organ to observe lesions and their response to therapy, but identifying and monitoring the progress of treatments of mouse skin diseases can still be challenging. This chapter provides an overview on how to use the laboratory mouse as a preclinical tool to evaluate efficacy of new compounds or test potential new uses for compounds approved for use for treating an unrelated disease. Basic approaches to handling mice, applying compounds, and quantifying effects of the treatment are presented.

Indexed as

Disease Models, AnimalAnimalsDose-Response Relationship, DrugDrug Administration RoutesDrug Delivery SystemsDrug Evaluation, PreclinicalHumansMiceSkinSkin DiseasesAlopecia areataAtopic dermatitisChronic proliferative dermatitisFull thickness skin graftsHairSkinXenograft

Identifiers

PMID27150092
PMCPMC5301944
OpenAlexW1507046295

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.