ArticleBMC evolutionary biology2016
R-gene variation across Arabidopsis lyrata subspecies: effects of population structure, selection and mating system.
Article in BMC evolutionary biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Transposable elements maintain genome-wide heterozygosity in inbred populations.Nature communications · 2022Article
- Drivers of linkage disequilibrium across a species' geographic range.PLoS genetics · 2021Article
- Contrasting genetic variation and positive selection followed the divergence of NBS-encoding genes in Asian and European pears.BMC genomics · 2020Article
- Changing environments and genetic variation: natural variation in inbreeding does not compromise short-term physiological responses.Proceedings. Biological sciences · 2019Article
- Restriction associated DNA-genotyping at multiple spatial scales in Arabidopsis lyrata reveals signatures of pathogen-mediated selection.BMC genomics · 2018Article
- Non-host Resistance Induced by theFrontiers in plant science · 2016Article
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Authors and funding
6 authors.
Funding
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Abstract
backgroundExamining allelic variation of R-genes in closely related perennial species of Arabidopsis thaliana is critical to understanding how population structure and ecology interact with selection to shape the evolution of innate immunity in plants. We finely sampled natural populations of Arabidopsis lyrata from the Great Lakes region of North America (A. l. lyrata) and broadly sampled six European countries (A. l. petraea) to investigate allelic variation of two R-genes (RPM1 and WRR4) and neutral genetic markers (Restriction Associated DNA sequences and microsatellites) in relation to mating system, phylogeographic structure and subspecies divergence.
resultsFine-scale sampling of populations revealed strong effects of mating system and population structure on patterns of polymorphism for both neutral loci and R-genes, with no strong evidence for selection. Broad geographic sampling revealed evidence of balancing selection maintaining polymorphism in R-genes, with elevated heterozygosity and diversity compared to neutral expectations and sharing of alleles among diverged subspecies. Codon-based tests detected both positive and purifying selection for both R-genes, as commonly found for animal immune genes.
conclusionsOur results highlight that combining fine and broad-scale sampling strategies can reveal the multiple factors influencing polymorphism and divergence at potentially adaptive genes such as R-genes.
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