Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016
Dopamine Increases a Value-Independent Gambling Propensity.
Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Bidirectional modulation of reward-guided decision making by dopamine.Psychopharmacology · 2025Trial
- Dopamine Receptor-Specific Contributions to the Computation of Value.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Trial
- Trial
- Trial
- Microstimulation of the human dopaminergic midbrain enhances outcome-related happiness and reduces loss seeking.bioRxiv : the preprint server for biology · 2026Article
- Sense of agency and decision making.Frontiers in psychology · 2026Article
- Surprising sounds influence risky decision making.Nature communications · 2024Article
- Double dissociation of dopamine and subthalamic nucleus stimulation on effortful cost/benefit decision making.Current biology : CB · 2024Article
- Multiple timescales of temporal context in risky choice: Behavioral identification and relationships to physiological arousal.PloS one · 2024Article
- The influence of insight on risky decision making and nucleus accumbens activation.Scientific reports · 2023Article
- Decomposing risky decision-making in methamphetamine use disorder: Behavioral updating and D2 dopamine receptors.Drug and alcohol dependence · 2023Article
- Toward a Unifying Account of Dopamine's Role in Cost-Benefit Decision Making.Biological psychiatry global open science · 2023Review
- Neuroimaging of Dopamine Transporter Density in the Striatum of Disordered Gamblers.Journal of gambling studies · 2023Article
- Dorsolateral prefrontal cortex plays causal role in probability weighting during risky choice.Scientific reports · 2022Article
- When Helping Is Risky: The Behavioral and Neurobiological Trade-off of Social and Risk Preferences.Psychological science · 2021Article
- Testing models at the neural level reveals how the brain computes subjective value.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Dopamine-related striatal neurophysiology is associated with specialization of frontostriatal reward circuitry through adolescence.Progress in neurobiology · 2021Article
- Shifting uncertainty intolerance: methylphenidate and attention-deficit hyperactivity disorder.Translational psychiatry · 2021Article
- Using pharmacological manipulations to study the role of dopamine in human reward functioning: A review of studies in healthy adults.Neuroscience and biobehavioral reviews · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Although the impact of dopamine on reward learning is well documented, its influence on other aspects of behavior remains the subject of much ongoing work. Dopaminergic drugs are known to increase risk-taking behavior, but the underlying mechanisms for this effect are not clear. We probed dopamine's role by examining the effect of its precursor L-DOPA on the choices of healthy human participants in an experimental paradigm that allowed particular components of risk to be distinguished. We show that choice behavior depended on a baseline (ie, value-independent) gambling propensity, a gambling preference scaling with the amount/variance, and a value normalization factor. Boosting dopamine levels specifically increased just the value-independent baseline gambling propensity, leaving the other components unaffected. Our results indicate that the influence of dopamine on choice behavior involves a specific modulation of the attractiveness of risky options-a finding with implications for understanding a range of reward-related psychopathologies including addiction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.