ArticlePloS one2016
Low AMY1 Gene Copy Number Is Associated with Increased Body Mass Index in Prepubertal Boys.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 54 citations in OpenAlex.
- Salivary Amylase Gene Copy Number Relates with BMI Z-Score and with Response to Lifestyle Intervention for Children with Overweight and Obesity.International journal of molecular sciences · 2025Trial
- Reduced odds of diabetes associated with high plasma salivary α-amylase activity in Qatari women: a cross-sectional study.Scientific reports · 2021Trial
- Trial
- Trial
- Body Mass Index and Inter-Individual Variation in Salivary Amylase Gene Copy Number Assessed Using an In-House Validated Method: A Pilot Study from the National Nutrition Survey of a High Rice-Consuming Nation.Lifestyle genomics · 2026Article
- Obesity Parameters in Women Is Associated With AMY1 Gene Copy Number, Nesfatin-1 Level, and Dietary Intake: A Case-Control Study.Molecular nutrition & food research · 2025Article
- A genomics perspective of personalized prevention and management of obesity.Human genomics · 2024Review
- Salivary amylase gene (AMY1) copy number variation has only a minor correlation with body composition in Chinese adults.Genes & genomics · 2023Article
- [From genotype to phenotype: amylase gene in childhood obesity].Revista medica del Instituto Mexicano del Seguro Social · 2023Review
- Impact of salivary and pancreatic amylase gene copy numbers on diabetes, obesity, and functional profiles of microbiome in Northern Japanese population.Scientific reports · 2022Article
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- Effect of AMY1 copy number variation and various doses of starch intake on glucose homeostasis: data from a cross-sectional observational study and a crossover meal study.Genes & nutrition · 2021Article
- Dietary carbohydrates interact with AMY1 polymorphisms to influence the incidence of type 2 diabetes in Korean adultsScientific reports · 2021Article
- Ethnic-specific association of amylase gene copy number with adiposity traits in a large Middle Eastern biobank.NPJ genomic medicine · 2021Article
- Association of Serum Amylase Activity and the Copy Number Variation ofDiabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Alpha-amylase 1A copy number variants and the association with memory performance and Alzheimer's dementia.Alzheimer's research & therapy · 2020Article
- High plasma salivary α-amylase, but not high AMY1 copy number, associated with low obesity rate in Qatari adults: cross-sectional study.Scientific reports · 2020Article
- An Evolutionary Perspective on the Impact of Genomic Copy Number Variation on Human Health.Journal of molecular evolution · 2020Review
- Salivary Amylase Gene Copy Number Is Associated with the Obesity and Inflammatory Markers in Children.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Interaction Effect Between Copy Number Variation in Salivary Amylase Locus (Frontiers in nutrition · 2020Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenome-wide association studies have identified more than 60 single nucleotide polymorphisms associated with Body Mass Index (BMI). Additional genetic variants, such as copy number variations (CNV), have also been investigated in relation to BMI. Recently, the highly polymorphic CNV in the salivary amylase (AMY1) gene, encoding an enzyme implicated in the first step of starch digestion, has been associated with obesity in adults and children. We assessed the potential association between AMY1 copy number and a wide range of BMI in a population of Italian school-children.
methods744 children (354 boys, 390 girls, mean age (±SD): 8.4±1.4years) underwent anthropometric assessments (height, weight) and collection of saliva samples for DNA extraction. AMY1 copies were evaluated by quantitative PCR.
resultsA significant increase of BMI z-score by decreasing AMY1 copy number was observed in boys (β: -0.117, p = 0.033), but not in girls. Similarly, waist circumference (β: -0.155, p = 0.003, adjusted for age) was negatively influenced by AMY1 copy number in boys. Boys with 8 or more AMY1 copy numbers presented a significant lower BMI z-score (p = 0.04) and waist circumference (p = 0.01) when compared to boys with less than 8 copy numbers.
conclusionsIn this pediatric-only, population-based study, a lower AMY1 copy number emerged to be associated with increased BMI in boys. These data confirm previous findings from adult studies and support a potential role of a higher copy number of the salivary AMY1 gene in protecting from excess weight gain.
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