ReviewThe FEBS journal2016
Using CRISPR/Cas to study gene function and model disease in vivo.
Review in The FEBS journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Engineering a CRISPRoff Platform to Modulate Expression of Myeloid Cell Leukemia (MCL-1) in Committed Oligodendrocyte Neural Precursor Cells.Bio-protocol · 2024Article
- TALENs-an indispensable tool in the era of CRISPR: a mini review.Journal, genetic engineering & biotechnology · 2021Review
- Tissue-specific activation of gene expression by the Synergistic Activation Mediator (SAM) CRISPRa system in mice.Nature communications · 2021Article
- Article
- Direct genome editing of patient-derived xenografts using CRISPR-Cas9 enables rapidNature cancer · 2020Article
- Cancer diagnosis and immunotherapy in the age of CRISPR.Genes, chromosomes & cancer · 2019Review
- Genomic evolution of cancer models: perils and opportunities.Nature reviews. Cancer · 2019Review
- Generating mouse models for biomedical research: technological advances.Disease models & mechanisms · 2019Review
- Biological Characteristics of Severe Combined Immunodeficient Mice Produced by CRISPR/Cas9-MediatedFrontiers in genetics · 2019Article
- Emerging applications of genome-editing technology to examine functionality of GWAS-associated variants for complex traits.Physiological genomics · 2018Review
- The past and presence of gene targeting: from chemicals and DNA via proteins to RNA.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Epigenetic Targeting of Granulin in Hepatoma Cells by Synthetic CRISPR dCas9 Epi-suppressors.Molecular therapy. Nucleic acids · 2018Article
- Safety and Efficacy of AAV Retrograde Pancreatic Ductal Gene Delivery in Normal and Pancreatic Cancer Mice.Molecular therapy. Methods & clinical development · 2018Article
- Unraveling of Central Nervous System Disease Mechanisms Using CRISPR Genome Manipulation.Journal of central nervous system disease · 2018Review
- CRISPR Editing Technology in Biological and Biomedical Investigation.Journal of cellular biochemistry · 2017Review
- A CRISPR toolbox to study virus-host interactions.Nature reviews. Microbiology · 2017Review
- The Interaction of Genetic Background and Mutational Effects in Regulation of Mouse Craniofacial Shape.G3 (Bethesda, Md.) · 2017Article
- A perspective ofGenes and environment : the official journal of the Japanese Environmental Mutagen Society · 2017Article
- Patterns of CRISPR/Cas9 activity in plants, animals and microbes.Plant biotechnology journal · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The recent discovery of the CRISPR/Cas system and repurposing of this technology to edit a variety of different genomes have revolutionized an array of scientific fields, from genetics and translational research, to agriculture and bioproduction. In particular, the prospect of rapid and precise genome editing in laboratory animals by CRISPR/Cas has generated an immense interest in the scientific community. Here we review current in vivo applications of CRISPR/Cas and how this technology can improve our knowledge of gene function and our understanding of biological processes in animal models.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.