Evidence map›Paper›PMID 27149520›Full record

ArticleChannels (Austin, Tex.)2016

A Ca

Yuriy Rzhepetskyy, Joanna Lazniewska, Juliane Proft, Marta Campiglio, Bernhard E Flucher, Norbert Weiss

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Channels (Austin, Tex.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. The T-type calcium channelosome.Pflugers Archiv : European journal of physiology · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. The life cycle of voltage-gated CaNeuronal signaling · 2021
    Review
  7. Stac protein regulates release of neuropeptides.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  8. Contribution of T-Type Calcium Channels to Spinal Cord Injury-Induced Hyperexcitability of Nociceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  9. Neuronal Cav3 channelopathies: recent progress and perspectives.Pflugers Archiv : European journal of physiology · 2020
    Review
  10. Article
  11. Article
  12. Genetic T-type calcium channelopathies.Journal of medical genetics · 2020
    Review
  13. CACHD1 is an α2δ-Like Protein That Modulates CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
  14. Stac Proteins Suppress CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
  15. Duplex signaling by CaM and Stac3 enhances CaThe Journal of general physiology · 2018
    Article
  16. Article
  17. Role of individual S4 segments in gating of CaChannels (Austin, Tex.) · 2018
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Yuriy Rzhepetskyya Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic , Prague , Czech Republic.
Joanna Lazniewskaa Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic , Prague , Czech Republic.
Juliane Profta Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic , Prague , Czech Republic.
Marta Campigliob Division of Physiology, Department of Physiology and Medical Physics, Medical University Innsbruck , Innsbruck , Austria.
Bernhard E Flucherb Division of Physiology, Department of Physiology and Medical Physics, Medical University Innsbruck , Innsbruck , Austria.
Norbert Weissa Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic , Prague , Czech Republic.
Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry · CZInnsbruck Medical University · AT

Funding

Austrian Science Fund FWF P 23479Austrian Science Fund FWF P 27031
6 · The paper itself

Abstract

Low-voltage-activated T-type calcium channels are essential contributors to neuronal physiology where they play complex yet fundamentally important roles in shaping intrinsic excitability of nerve cells and neurotransmission. Aberrant neuronal excitability caused by alteration of T-type channel expression has been linked to a number of neuronal disorders including epilepsy, sleep disturbance, autism, and painful chronic neuropathy. Hence, there is increased interest in identifying the cellular mechanisms and actors that underlie the trafficking of T-type channels in normal and pathological conditions. In the present study, we assessed the ability of Stac adaptor proteins to associate with and modulate surface expression of T-type channels. We report the existence of a Ca

Indexed as

Calcium Channels, T-TypeCell MembraneHEK293 CellsHumansNerve Tissue ProteinsCACNA1H protein, humanCalcium Channels, T-TypeNerve Tissue ProteinsCav3.2 channelStac adaptor proteintraffickingT-type calcium channel

Identifiers

PMID27149520
PMCPMC4988463
OpenAlexW2345491912

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.