ArticlePloS one2016
Sensitization of the Nociceptive System in Complex Regional Pain Syndrome.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pain mechanisms in complex regional pain syndrome: a systematic review and meta-analysis of quantitative sensory testing outcomes.Journal of orthopaedic surgery and research · 2023Pooled it
- The role of biopsychosocial factors in classifying pain intensity across various chronic pain conditions.Scientific reports · 2026Article
- The N13 somatosensory evoked potential in complex regional pain syndrome - A potential marker for central sensitization?Clinical neurophysiology practice · 2026Article
- Intact endogenous pain inhibition in complex regional pain syndrome type 1.Pain reports · 2025Article
- A brief review of complex regional pain syndrome and current management.Annals of medicine · 2024Review
- Is CRPS-1 a Chronic Disabling Disease? A Long-term, Real-Life Study on Patients Treated With Neridronate.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2024Article
- Contact-Heat Evoked Potentials: Insights into Pain Processing in CRPS Type I.Journal of pain research · 2024Article
- Sensory phenotypes in complex regional pain syndrome and chronic low back pain-indication of common underlying pathomechanisms.Pain reports · 2023Article
- Somatotopic disruption of the functional connectivity of the primary sensorimotor cortex in complex regional pain syndrome type 1.Human brain mapping · 2023Article
- Central sensitization in CRPS patients with widespread pain: a cross-sectional study.Pain medicine (Malden, Mass.) · 2023Article
- Pain-autonomic measures reveal nociceptive sensitization in complex regional pain syndrome.European journal of pain (London, England) · 2023Article
- Different Types of Pain in Complex Regional Pain Syndrome Require a Personalized Treatment Strategy.Journal of pain research · 2023Review
- Central Sensitization and Psychological State Distinguishing Complex Regional Pain Syndrome from Other Chronic Limb Pain Conditions: A Cluster Analysis Model.Biomedicines · 2022Article
- Determinants of Complex Regional Pain Syndrome Type I among Radial Head Fracture Patients with Unilateral Arthroplasty.Orthopaedic surgery · 2022Observational
- Bier block as a successful management of a patient with intractable complex regional pain syndrome (CRPS) type 1: A case report.Clinical case reports · 2021Article
- Bradykinin Receptors Play a Critical Role in the Chronic Post-ischaemia Pain Model.Cellular and molecular neurobiology · 2021Article
- Cross Cultural Adaptation and Validation of Italian Version of the Leeds Assessment of Neuropathic Symptoms and Signs Scale and Pain DETECT Questionnaire for the Distinction between Nociceptive and Neuropathic Pain.Pain research & management · 2021Article
- Altered sensory-motor plasticity in amyotrophic lateral sclerosis and complex regional pain type I syndrome: a shared mechanism?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Highlighting the Role of Biomarkers of Inflammation in the Diagnosis and Management of Complex Regional Pain Syndrome.Molecular diagnosis & therapy · 2019Review
- Transcriptome profiling of dorsal root ganglia in a rat model of complex regional pain syndrome type-I reveals potential mechanisms involved in pain.Journal of pain research · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundComplex regional pain syndrome type I (CRPS-I) is characterized by sensory, motor and autonomic abnormalities without electrophysiological evidence of a nerve lesion.
objectiveAims were to investigate how sensory, autonomic and motor function change in the course of the disease.
methods19 CRPS-I patients (17 with acute, 2 with chronic CRPS, mean duration of disease 5.7±8.3, range 1-33 months) were examined with questionnaires (LANSS, NPS, MPI, Quick DASH, multiple choice list of descriptors for sensory, motor, autonomic symptoms), motor and autonomic tests as well as quantitative sensory testing according to the German Research Network on Neuropathic Pain at two visits (baseline and 36±10.6, range 16-53 months later).
resultsCRPS-I patients had an improvement of sudomotor and vasomotor function, but still a great impairment of sensory and motor function upon follow-up. Although pain and mechanical detection improved upon follow-up, thermal and mechanical pain sensitivity increased, including the contralateral side. Increase in mechanical pain sensitivity and loss of mechanical detection were associated with presence of ongoing pain.
conclusionsThe results demonstrate that patients with CRPS-I show a sensitization of the nociceptive system in the course of the disease, for which ongoing pain seems to be the most important trigger. They further suggest that measured loss of function in CRPS-I is due to pain-induced hypoesthesia rather than a minimal nerve lesion. In conclusion, this article gives evidence for a pronociceptive pain modulation profile developing in the course of CRPS and thus helps to assess underlying mechanisms of CRPS that contribute to the maintenance of patients' pain and disability.
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Registered trials
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