ArticlePloS one2016
Abandonment of Treatment for Latent Tuberculosis Infection and Socioeconomic Factors in Children and Adolescents: Rio De Janeiro, Brazil.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 27 citations in OpenAlex.
- HOW CAN NEW TECHNOLOGIES HELP REDUCE ABSENTEEISM IN PEDIATRIC CONSULTATION?Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2020Trial
- Mycobacterium tuberculosis transmission among child and adolescent contacts of people with pulmonary tuberculosis in Brazil: a multi-center prospective cohort study.BMC infectious diseases · 2025Observational
- TB preventive therapy preferences among children and adolescents.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2023Article
- Determinants of losses in the tuberculosis infection cascade of care among children and adolescent contacts of pulmonary tuberculosis cases: A Brazilian multi-centre longitudinal study.Lancet regional health. Americas · 2022Article
- Barriers and facilitators for isoniazid preventive therapy (IPT) administration in children under 5 years of age in the Dominican Republic.BMC infectious diseases · 2022Article
- Telehealth Reduces Missed Appointments in Pediatric Patients with Tuberculosis Infection.Tropical medicine and infectious disease · 2022Article
- Determinants of losses in the latent tuberculosis infection cascade of care in Brazil.BMJ global health · 2021Article
- Caregivers' knowledge and perceptions are associated with children's TB preventive treatment completion.Public health action · 2021Article
- A scoping review of paediatric latent tuberculosis infection care cascades: initial steps are lacking.BMJ global health · 2021Article
- Determinants of losses in the latent tuberculosis cascade of care in Brazil: A retrospective cohort study.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020Article
- [Factors associated with completion of isoniazid preventive therapy in children in Quito, Ecuador (2014-2016 and 2018)Fatores associados à adesão à terapia preventiva com isoniazida em crianças de Quito, Equador (2014-2016 e 2018)].Revista panamericana de salud publica = Pan American journal of public health · 2019Article
- Effects of preventive therapy for latent tuberculosis infection and factors associated with treatment abandonment: a cross-sectional study.Journal of thoracic disease · 2018Article
- Epidemiological aspects, clinical manifestations, and prevention of pediatric tuberculosis from the perspective of the End TB Strategy.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2018Review
- Social determinants of pulmonary tuberculosis treatment non-adherence in Rio de Janeiro, Brazil.PloS one · 2018Article
- Tuberculosis preventive treatment in children and adolescents: an observational study of secondary data.Jornal de pediatriaObservational
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRoutine data on the use of isoniazid preventive therapy (IPT) in children and adolescents are scarce in high tuberculosis (TB) burden countries.
objectiveTo describe the factors related to abandonment of IPT in children and adolescents with latent tuberculosis infection (LTBI) receiving routine care.
methodsRetrospective (2005-2009) descriptive study of 286 LTBI cases with indication of IPT and serviced at a pediatric hospital in the State of Rio de Janeiro, Brazil. Survival analysis of the risk of abandonment of IPT over six months was performed, including multivariate analysis using the Cox proportional hazards model.
resultsOut of the 245 cases of LTBI included, 62 abandoned IPT (25.3%; 95% CI: 20%-31%). On multivariate analysis, the variables related to the IPT abandonment hazard ratio were the Human Development Index (HDI) (hazard ratio-HR: 0.004; 0.000-0.569) of the place of residence and the contact with adults that were not undergoing anti-TB treatment (HR: 7.30; 1.00-53.3).
conclusionThis study reveals the relevance of the relation of abandonment of IPT to the socioeconomic conditions at the place of residence and poor adherence to the active TB treatment. Educational measures to stimulate preventive treatment of child contacts and curative treatment of index cases should target the full familial setting.
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