ArticlePloS one2016
Optic Disc Perfusion in Primary Open Angle and Normal Tension Glaucoma Eyes Using Optical Coherence Tomography-Based Microangiography.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
78 citing papers in PubMed, 136 citations in OpenAlex.
- Optical coherence tomography angiography of the peripapillary capillaries in primary open-angle and normal-tension glaucoma.PloS one · 2017Trial
- ET-1, MMPs, ZAG, and APN Link Reduced Ocular Perfusion to Glaucoma.Biomolecules · 2025Article
- OCT Angiography of the Retina and the Choroid in the Macula in Patients with Normal Tension Glaucoma and Primary Open Angle Glaucoma.Diagnostics (Basel, Switzerland) · 2024Article
- Diagnostic ability of the combination of retinal microvasculature evaluation and static automated perimetry for early primary open-angle glaucoma.Lasers in medical science · 2024Article
- Comparison between open-angle glaucoma and angle-closure glaucoma regarding the short-term optic disc vessel density changes after trabeculectomy.Lasers in medical science · 2023Article
- The Differences in the Pattern of OCT and OCTA Examinations between Early Normal- and High-Tension Pseudoexfoliative Glaucoma.Journal of clinical medicine · 2023Article
- Macular and Peripapillary Vascular Densities in Non-Glaucomatous Eyes of Patients with Unilateral Glaucoma.Turkish journal of ophthalmology · 2023Article
- Retinal vessel architecture and geometry are not impaired in normal-tension glaucoma.Scientific reports · 2023Article
- Ocular pulse amplitude and visual field changes in patients diagnosed with aortic regurgitation.International ophthalmology · 2023Article
- OCTA and Doppler Ultrasound in Primary Open-Angle Glaucoma and Normal-Tension Glaucoma.Life (Basel, Switzerland) · 2023Article
- Deep Learning with a Dataset Created Using Kanno Saitama Macro, a Self-Made Automatic Foveal Avascular Zone Extraction Program.Journal of clinical medicine · 2022Article
- A narrative review on the association of high intraocular pressure and glaucoma in patients with retinal vein occlusion.Annals of translational medicine · 2022Review
- The Association Between Regional Macula Vessel Density and Central Visual Field Damage in Advanced Glaucoma Eyes.Journal of glaucoma · 2022Article
- Quantitative Measurements of Vessel Density and Blood Flow Areas Primary Angle Closure Diseases: A Study of Optical Coherence Tomography Angiography.Journal of clinical medicine · 2022Article
- Diagnostic ability and sectoral structure-function relationship of circumpapillary and macular superficial vessel density in early glaucomatous eyes.Scientific reports · 2022Article
- Normal tension glaucoma: A dynamic optical coherence tomography angiography study.Frontiers in medicine · 2022Article
- OCT angiography measured changes in the foveal avascular zone area after glaucoma surgery.The British journal of ophthalmology · 2022Article
- Distance between the center of the FAZ measured automatically and the highest foveal bulge using OCT-angiography in elderly healthy eyes.Scientific reports · 2021Article
- Comparative study of optical coherence tomography angiography algorithms for rodent retinal imaging.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Optical Coherence Tomography and Glaucoma.Annual review of vision science · 2021Review
18 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 1 institution in 2 countries.
Funding
Abstract
purposeTo investigate optic disc perfusion differences in normal, primary open-angle glaucoma (POAG), and normal tension glaucoma (NTG) eyes using optical microangiography (OMAG) based optical coherence tomography (OCT) angiography technique.
designCross-sectional, observational study. SUBJECTS: Twenty-eight normal, 30 POAG, and 31 NTG subjects.
methodsOne eye from each subject was scanned with a 68 kHz Cirrus HD-OCT 5,000-based OMAG prototype system centered at the optic nerve head (ONH) (Carl Zeiss Meditec Inc, Dublin, CA). Microvascular images were generated from the OMAG dataset by detecting the differences in OCT signal between consecutive B-scans. The pre-laminar layer (preLC) was isolated by a semi-automatic segmentation program.
main outcome measuresOptic disc perfusion, quantified as flux, vessel area density, and normalized flux (flux normalized by the vessel area) within the ONH.
resultsGlaucomatous eyes had significantly lower optic disc perfusion in preLC in all three perfusion metrics (p<0.0001) compared to normal eyes. The visual field (VF) mean deviation (MD) and pattern standard deviation (PSD) were similar between the POAG and NTG groups, and no differences in optic disc perfusion were observed between POAG and NTG. Univariate analysis revealed significant correlation between optic disc perfusion and VF MD, VF PSD, and rim area in both POAG and NTG groups (p≤0.0288). However, normalized optic disc perfusion was correlated with some structural measures (retinal nerve fiber layer thickness and ONH cup/disc ratio) only in POAG eyes.
conclusionsOptic disc perfusion detected with OMAG was significantly reduced in POAG and NTG groups compared to normal controls, but no difference was seen between POAG and NTG groups with similar levels of VF damage. Disc perfusion was significantly correlated with VF MD, VF PSD, and rim area in glaucomatous eyes. Vascular changes at the optic disc as measured using OMAG may provide useful information for diagnosis and monitoring of glaucoma.
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Registered trials
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