ArticleNature medicine2016
Facilitating a culture of responsible and effective sharing of cancer genome data.
Article in Nature medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer.Nature genetics · 2020Pooled it
- Factors influencing harmonized health data collection, sharing and linkage in Denmark and Switzerland: A systematic review.PloS one · 2019Pooled it
- A call to action to scale up research and clinical genomic data sharing.Nature reviews. Genetics · 2025Review
- Organizational Factors in Clinical Data Sharing for Artificial Intelligence in Health Care.JAMA network open · 2023Article
- The pharmacoepigenomic landscape of cancer cell lines reveals the epigenetic component of drug sensitivity.Communications biology · 2023Article
- A patient-driven clinicogenomic partnership for metastatic prostate cancer.Cell genomics · 2022Article
- Identification and Assessment of Risks in Biobanking: The Case of the Cancer Institute of Bari.Cancers · 2022Article
- Delivering precision oncology to patients with cancer.Nature medicine · 2022Review
- Federated analysis of BRCA1 and BRCA2 variation in a Japanese cohort.Cell genomics · 2022Article
- A Blockchain-Based Dynamic Consent Architecture to Support Clinical Genomic Data Sharing (ConsentChain): Proof-of-Concept Study.JMIR medical informatics · 2021Article
- A showcase study on personalized in silico drug response prediction based on the genetic landscape of muscle invasive bladder cancer.Scientific reports · 2021Article
- Phenotypically Similar Rare Disease Identification from an Integrative Knowledge Graph for Data Harmonization: Preliminary Study.JMIR medical informatics · 2020Article
- The omics discovery REST interface.Nucleic acids research · 2020Article
- Implementing the FAIR Data Principles in precision oncology: review of supporting initiatives.Briefings in bioinformatics · 2020Review
- CAncer bioMarker Prediction Pipeline (CAMPP)-A standardized framework for the analysis of quantitative biological data.PLoS computational biology · 2020Article
- Development of a Precision Medicine Workflow in Hematological Cancers, Aalborg University Hospital, Denmark.Cancers · 2020Article
- The future of genomics in Ireland - focus on genomics for health.HRB open research · 2020Article
- Trust in genomic data sharing among members of the general public in the UK, USA, Canada and Australia.Human genetics · 2019Article
- New functionalities in the TCGAbiolinks package for the study and integration of cancer data from GDC and GTEx.PLoS computational biology · 2019Article
- Cooperating on Data: The Missing Element in Bringing Real Innovation to Europe's Healthcare Systems.Public health genomics · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Funding
Abstract
Rapid and affordable tumor molecular profiling has led to an explosion of clinical and genomic data poised to enhance the diagnosis, prognostication and treatment of cancer. A critical point has now been reached at which the analysis and storage of annotated clinical and genomic information in unconnected silos will stall the advancement of precision cancer care. Information systems must be harmonized to overcome the multiple technical and logistical barriers to data sharing. Against this backdrop, the Global Alliance for Genomic Health (GA4GH) was established in 2013 to create a common framework that enables responsible, voluntary and secure sharing of clinical and genomic data. This Perspective from the GA4GH Clinical Working Group Cancer Task Team highlights the data-aggregation challenges faced by the field, suggests potential collaborative solutions and describes how GA4GH can catalyze a harmonized data-sharing culture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.