Regulation of pancreatic cancer aggressiveness by stromal stiffening.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

18 citing papers in PubMed.

1. Nanomaterial-assisted pancreatic cancer theranostics.Regenerative biomaterials · 2025
   Review
2. A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer.Cell chemical biology · 2024
   Article
3. Glycogen synthase kinase 3β: the nexus of chemoresistance, invasive capacity, and cancer stemness in pancreatic cancer.Cancer drug resistance (Alhambra, Calif.) · 2024
   Review
4. Metabolic reprogramming by driver mutation-tumor microenvironment interplay in pancreatic cancer: new therapeutic targets.Cancer metastasis reviews · 2021
   Review
5. The Extracellular Matrix in Pancreatic Cancer: Description of a Complex Network and Promising Therapeutic Options.Cancers · 2021
   Review
6. Ocoxin Increases the Antitumor Effect of BRAF Inhibition and Reduces Cancer Associated Fibroblast-Mediated Chemoresistance and Protumoral Activity in Metastatic Melanoma.Nutrients · 2021
   Article
7. Emerging roles for the IL-6 family of cytokines in pancreatic cancer.Clinical science (London, England : 1979) · 2020
   Review
8. Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy.Small GTPases · 2020
   Review
9. Collagen content and extracellular matrix cause cytoskeletal remodelling in pancreatic fibroblasts.Journal of the Royal Society, Interface · 2019
   Article
10. Turning foes to friends: targeting cancer-associated fibroblasts.Nature reviews. Drug discovery · 2019
    Review
11. Subcutaneous Inoculation of 3D Pancreatic Cancer Spheroids Results in Development of Reproducible Stroma-Rich Tumors.Translational oncology · 2019
    Article
12. Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer.Gut · 2018
    Article
13. Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth.Cancer research · 2018
    Article
14. Biomimetic and enzyme-responsive dynamic hydrogels for studying cell-matrix interactions in pancreatic ductal adenocarcinoma.Biomaterials · 2018
    Article
15. Defining the Role of Solid Stress and Matrix Stiffness in Cancer Cell Proliferation and Metastasis.Frontiers in oncology · 2018
    Review
16. Synthetic essentiality: Targeting tumor suppressor deficiencies in cancer.BioEssays : news and reviews in molecular, cellular and developmental biology · 2017
    Review
17. ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth.EMBO molecular medicine · 2017
    Article
18. ROCK signalling induced gene expression changes in mouse pancreatic ductal adenocarcinoma cells.Scientific data · 2016
    Article

Corrections and comments

• Comment on
  Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.2016

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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