ArticlePloS one2016
Development and Characterization of a Macaque Model of Focal Internal Capsular Infarcts.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Motor Impairment and Adaptation in a Novel Nonhuman Primate Model of Internal Capsule Infarct.Stroke · 2026Article
- Functional Near-Infrared Spectroscopy Reveals Functional Rewiring between Macaque Motor Areas Following Postinfarction Recovery of Manual Dexterity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Absence of cortical reorganization following an internal capsule stroke in rodents.bioRxiv : the preprint server for biology · 2025Article
- The pathogenesis of cerebral small vessel disease and vascular cognitive impairment.Physiological reviews · 2025Review
- White and Gray Matter Abnormalities in Young Adult Females with Dependent Personality Disorder: A Diffusion-Tensor Imaging and Voxel-Based Morphometry Study.Brain topography · 2024Article
- Time course of recovery of different motor functions following a reproducible cortical infarction in non-human primates.Frontiers in neurology · 2023Article
- Structural plasticity of motor cortices assessed by voxel-based morphometry and immunohistochemical analysis following internal capsular infarcts in macaque monkeys.Cerebral cortex communications · 2022Article
- Precision Capsular Infarct Modeling to Produce Hand Motor Deficits in Cynomolgus Macaques.Experimental neurobiology · 2021Article
- Non-human Primate Models to Explore the Adaptive Mechanisms After Stroke.Frontiers in systems neuroscience · 2021Review
- Functional near-infrared-spectroscopy-based measurement of changes in cortical activity in macaques during post-infarct recovery of manual dexterity.Scientific reports · 2020Article
- Targeted Infarction of the Internal Capsule in the Rat Using Microstimulation Guidance.Stroke · 2019Article
- Functional near-infrared spectroscopy for monitoring macaque cerebral motor activity during voluntary movements without head fixation.Scientific reports · 2018Article
- Focal Malonate Injection Into the Internal Capsule of Rats as a Model of Lacunar Stroke.Frontiers in neurology · 2018Article
- Motor compensation and its effects on neural reorganization after stroke.Nature reviews. Neuroscience · 2017Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Several studies have used macaque monkeys with lesions induced in the primary motor cortex (M1) to investigate the recovery of motor function after brain damage. However, in human stroke patients, the severity and outcome of motor impairments depend on the degree of damage to the white matter, especially that in the posterior internal capsule, which carries corticospinal tracts. To bridge the gap between results obtained in M1-lesioned macaques and the development of clinical intervention strategies, we established a method of inducing focal infarcts at the posterior internal capsule of macaque monkeys by injecting endothelin-1 (ET-1), a vasoconstrictor peptide. The infarcts expanded between 3 days and 1 week after ET-1 injection. The infarct volume in each macaque was negatively correlated with precision grip performance 3 days and 1 week after injection, suggesting that the degree of infarct expansion may have been a cause of the impairment in hand movements during the early stage. Although the infarct volume decreased and gross movement improved, impairment of dexterous hand movements remained until the end of the behavioral and imaging experiments at 3 months after ET-1 injection. A decrease in the abundance of large neurons in M1, from which the descending motor tracts originate, was associated with this later-stage impairment. The present model is useful not only for studying neurological changes underlying deficits and recovery but also for testing therapeutic interventions after white matter infarcts in primates.
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