ArticleAnalytical chemistry2016
Deterministic Absolute Negative Mobility for Micro- and Submicrometer Particles Induced in a Microfluidic Device.
Article in Analytical chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- High-resolution 3D-printed insulator-based dielectrophoresis devices for biomolecular manipulation.Analytical and bioanalytical chemistry · 2026Article
- Assessing the Discriminatory Capabilities of iEK Devices under DC and DC-Biased AC Stimulation Potentials.Micromachines · 2023Article
- Modular microfluidics for life sciences.Journal of nanobiotechnology · 2023Review
- Continuous organelle separation in an insulator-based dielectrophoretic device.Electrophoresis · 2022Article
- [Research progress in the application of external field separation technology and microfluidic technology in the separation of micro/nanoscales].Se pu = Chinese journal of chromatography · 2021Review
- Microscale nonlinear electrokinetics for the analysis of cellular materials in clinical applications: a review.Mikrochimica acta · 2021Review
- Tunable particle separation via deterministic absolute negative mobility.Scientific reports · 2020Article
- Low frequency cyclical potentials for fine tuning insulator-based dielectrophoretic separations.Biomicrofluidics · 2019Article
- Deterministic Ratchet for Sub-micrometer (Bio)particle Separation.Analytical chemistry · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Efficient separations of particles with micron and submicron dimensions are extremely useful in preparation and analysis of materials for nanotechnological and biological applications. Here, we demonstrate a nonintuitive, yet efficient, separation mechanism for μm and subμm colloidal particles and organelles, taking advantage of particle transport in a nonlinear post array in a microfluidic device under the periodic action of electrokinetic and dielectrophoretic forces. We reveal regimes in which deterministic particle migration opposite to the average applied force occurs for a larger particle, a typical signature of deterministic absolute negative mobility (dANM), whereas normal response is obtained for smaller particles. The coexistence of dANM and normal migration was characterized and optimized in numerical modeling and subsequently implemented in a microfluidic device demonstrating at least 2 orders of magnitude higher migration speeds as compared to previous ANM systems. We also induce dANM for mouse liver mitochondria and envision that the separation mechanisms described here provide size selectivity required in future separations of organelles, nanoparticles, and protein nanocrystals.
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