Evidence map›Paper›PMID 27148546›Full record

ArticleJournal of cardiovascular development and disease2016

Transcriptional Regulation of Heart Development in Zebrafish.

Fei Lu, Adam D Langenbacher, Jau-Nian Chen

Abstract read
In one paragraph

Article in Journal of cardiovascular development and disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Fish-Ing for Enhancers in the Heart.International journal of molecular sciences · 2021
    Review
  8. Heart malformation is an early response to valproic acid in developing zebrafish.Naunyn-Schmiedeberg's archives of pharmacology · 2020
    Article
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Fei LuDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA.
Adam D LangenbacherDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA.
Jau-Nian ChenDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA.

Funding

Elucidating the molecular mechanisms regulating embryonic cardiac rhythmicityR01HL096980 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHEN, JAU-NIAN · 2010 to 2013
$1.5M
Small molecule screening for novel regulators of cardiac Ca2+ kinetics and rhythmR56HL126051 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHEN, JAU-NIAN, NAKANO, ATSUSHI · 2015 to 2015
$457k
Genetic regulation of cardiac proliferation during development and in regenerationR56HL129052 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHEN, JAU-NIAN, LIEN, CHING-LING E · 2015 to 2015
$399k
NHLBI NIH HHS R01 HL096980NHLBI NIH HHS R56 HL126051NHLBI NIH HHS R56 HL129052
6 · The paper itself

Abstract

Cardiac transcription factors orchestrate the complex cellular and molecular events required to produce a functioning heart. Misregulation of the cardiac transcription program leads to embryonic developmental defects and is associated with human congenital heart diseases. Recent studies have expanded our understanding of the regulation of cardiac gene expression at an additional layer, involving the coordination of epigenetic and transcriptional regulators. In this review, we highlight and discuss discoveries made possible by the genetic and embryological tools available in the zebrafish model organism, with a focus on the novel functions of cardiac transcription factors and epigenetic and transcriptional regulatory proteins during cardiogenesis.

Indexed as

epigenetic regulatorsheart developmenttranscription factorszebrafish

Identifiers

PMID27148546
PMCPMC4852312

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.