ReviewFrontiers in cellular and infection microbiology2016
Local and Long-Distance Calling: Conversations between the Gut Microbiota and Intra- and Extra-Gastrointestinal Tract Infections.
Review in Frontiers in cellular and infection microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Association between early-life antibiotic exposure and gut microbiome alterations linked to allergic diseases in children: a systematic review.European journal of medical research · 2025Pooled it
- Pooled it
- Malaria and the Microbiome: A Systematic Review.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Pooled it
- The gut microbiome in early life predicts malaria susceptibility.Frontiers in cellular and infection microbiology · 2026Article
- Construction of Predictive Machine Learning Model of Glioma-Associated Gut Microbiota.Brain and behavior · 2025Article
- Exploring the complexities of poultry respiratory microbiota: colonization, composition, and impact on health.Animal microbiome · 2024Review
- The Gut and the Translocated Microbiomes in HIV Infection: Current Concepts and Future Avenues.Pathogens & immunity · 2024Review
- The initial interplay between HIV and mucosal innate immunity.Frontiers in immunology · 2023Review
- Review
- Oral antibiotics perturbation on gut microbiota after prostate biopsy.Frontiers in cellular and infection microbiology · 2022Article
- Cross-talk between immune system and microbiota in COVID-19.Expert review of gastroenterology & hepatology · 2021Review
- Complementary Medicine and Self-Care Strategies in Women with (Recurrent) Urinary Tract and Vaginal Infections: A Cross-Sectional Study on Use and Perceived Effectiveness in The Netherlands.Antibiotics (Basel, Switzerland) · 2021Article
- Intestinal Microbiota-A Promising Target for Antiviral Therapy?Frontiers in immunology · 2021Review
- Gut Microbiota Reconstruction Following Host Infection with Blood-stage Plasmodium berghei ANKA Strain in a Murine Model.Current medical science · 2019Article
- Current Findings on Gut Microbiota Mediated Immune Modulation against Viral Diseases in Chicken.Viruses · 2019Review
- Houttuynia cordata polysaccharide alleviated intestinal injury and modulated intestinal microbiota in H1N1 virus infected mice.Chinese journal of natural medicines · 2019Article
- Alteration of Intestinal Flora Stimulates Pulmonary microRNAs to Interfere with Host Antiviral Immunity in Influenza.Molecules (Basel, Switzerland) · 2018Article
- Clinical significance and outcome of Aeromonas spp. infections among 204 adult patients.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Article
- Comparison of stool versus rectal swab samples and storage conditions on bacterial community profiles.BMC microbiology · 2017Article
- Rectal microbiota among HIV-uninfected, untreated HIV, and treated HIV-infected in Nigeria.AIDS (London, England) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Preservation of health from infectious diseases depends upon both mucosal and systemic immunity via the collaborative effort of innate and adaptive immune responses. The proficiency of host immunity stems from robust defense mechanisms--physical barriers and specialized immune cells--and a failure of these mechanisms leads to pathology. Intriguingly, immunocompetence to pathogens can be shaped by the gut microbiome as recent publications highlight a dynamic interplay between the gut microbiome and host susceptibility to infection. Modulation of host immunity to enteric pathogens has long been studied where gut bacteria shape multiple facts of both innate and adaptive immunity. Conversely, the impact of gut commensals on host immunity to extra-gastrointestinal (GI) tract infections has only recently been recognized. In this context, the gut microbiome can augment host immunity to extra-GI tract bacterial, viral, and parasitic pathogens. This review explores the research that affords insight into the role of the gut microbiome in various infectious diseases, with a particular emphasis on extra-GI tract infections. A better understanding of the link between the gut microbiome and infectious disease will be critical for improving global health in the years ahead.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.