ReviewFrontiers in oncology2016
The End of the Hysterectomy Epidemic and Endometrial Cancer Incidence: What Are the Unintended Consequences of Declining Hysterectomy Rates?
Review in Frontiers in oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- Menopausal Estrogen-Alone Therapy and Health Outcomes in Women With and Without Bilateral Oophorectomy: A Randomized Trial.Annals of internal medicine · 2019Trial
- Effects of spinal versus general anesthesia on serum oxidative stress markers and cytokine release after abdominal hysterectomy: a non-randomized trial.Scientific reports · 2025Article
- Uterine cancer incidence trends and 5-year relative survival by race/ethnicity and histology among women under 50 years.American journal of obstetrics and gynecology · 2024Article
- Regional practice variation in hysterectomy and the implementation of less invasive surgical procedures: A register-based study in the Netherlands.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Mitigating disparity?: Treatment patterns, survival, and recurrence rates by race, ethnicity, and hospital site across a large urban health system.Gynecologic oncology reports · 2024Article
- Deciphering DNA repair gene mutational landscape in uterine corpus endometrial carcinoma patients using next generation sequencing.American journal of cancer research · 2024Article
- The Carolina hysterectomy cohort (CHC): a novel case series of reproductive-aged hysterectomy patients across 10 hospitals in the US south.BMC women's health · 2023Article
- Variation in hysterectomy prevalence and trends among U.S. States and Territories-Behavioral Risk Factor Surveillance System, 2012-2020.Cancer causes & control : CCC · 2023Article
- Subtotal hysterectomy reviewed: a stable or aperture for stump cervical malignancy. A referral hospital experience.Przeglad menopauzalny = Menopause review · 2022Article
- Trends and predictors of hysterectomy prevalence among women in the United States.American journal of obstetrics and gynecology · 2022Article
- Survival for endometrial cancer as a second primary malignancy.Cancer medicine · 2022Article
- Cancer Surveillance Opportunities to Meet Prevention and Control Challenges.Journal of the National Cancer Institute · 2021Article
- Osthole suppresses the proliferation and induces apoptosis via inhibiting the PI3K/AKT signaling pathway of endometrial cancer JEC cells.Experimental and therapeutic medicine · 2021Article
- Prospective analysis of circulating metabolites and endometrial cancer risk.Gynecologic oncology · 2021Observational
- Racial/ethnic differences in anthropometric and hormone-related factors and endometrial cancer risk: the Multiethnic Cohort Study.British journal of cancer · 2021Article
- A Mixed Methods Study of Hysterectomy in a U.S. Sample of Deaf Women Who Use American Sign Language.Women's health reports (New Rochelle, N.Y.) · 2021Article
- Trends in Hysterectomy Incidence Rates During 2000-2015 in Denmark: Shifting from Abdominal to Minimally Invasive Surgical Procedures.Clinical epidemiology · 2021Article
- Endometrial Cancer Type 2 Incidence and Survival Disparities Within Subsets of the US Black Population.Frontiers in oncology · 2021Article
- Article
- LINC01410/miR-23c/CHD7 functions as a ceRNA network to affect the prognosis of patients with endometrial cancer and strengthen the malignant properties of endometrial cancer cells.Molecular and cellular biochemistry · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Population-level cancer incidence rates are one measure to estimate the cancer burden. The goal is to provide information on trends to measure progress against cancer at the population level and identify emerging patterns signifying increased risk for additional research and intervention. Endometrial cancer is the most common of the gynecologic malignancies but capturing the incidence of disease among women at risk (i.e., women with a uterus) is challenging and not routinely published. Decreasing rates of hysterectomy increase the number of women at risk for disease, which should be reflected in the denominator of the incidence rate calculation. Furthermore, hysterectomy rates vary within the United States by multiple factors including geographic location, race, and ethnicity. Changing rates of hysterectomy are important to consider when looking at endometrial cancer trends. By correcting for hysterectomy when calculating incidence rates of cancers of the uterine corpus, many of the disparities that have been assumed for this disease are diminished.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.