ArticleClinical and translational allergy2016
Cow's milk allergy in Dutch children: an epigenetic pilot survey.
Article in Clinical and translational allergy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Epigenetic insights into food allergy: The potential role of DNA methylation in diagnosis and management.The World Allergy Organization journal · 2026Review
- Disentangling Gut Microbiome Alterations in Children with Cow's Milk Allergy: Impact of Sex, Milk Elimination, and Family History of Allergies.Nutrients · 2026Article
- A Rare Case of Cow's Milk Protein Allergy in a 12-Hour Old Neonate With Rectal Bleeding.Case reports in pediatrics · 2026Article
- A systematic longitudinal study of microbiome: integrating temporal-spatial dimensions with causal and deep learning models.BMC genomics · 2025Article
- DNA methylation of food sensitization in a French-Canadian population.Clinical epigenetics · 2025Article
- The Etiology of IgE-Mediated Food Allergy: Potential Therapeutics and Challenges.International journal of molecular sciences · 2025Review
- Review
- Epigenomic and epigenetic investigations of food allergy.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024Review
- Pathogenesis of allergic diseases and implications for therapeutic interventions.Signal transduction and targeted therapy · 2023Review
- Trained innate immunity, epigenetics, and food allergy.Frontiers in allergy · 2023Review
- Genome-wide DNA methylation status of Mongolians exhibits signs of cellular stress response related to their nomadic lifestyle.Journal of physiological anthropology · 2022Article
- Enhanced expression of endogenous retroviruses and of TRIM28 and SETDB1 in children with food allergy.Clinical and translational allergy · 2022Article
- Epigenetics in Food Allergy and Immunomodulation.Nutrients · 2021Review
- Allergic Diseases: A Comprehensive Review on Risk Factors, Immunological Mechanisms, Link with COVID-19, Potential Treatments, and Role of Allergen Bioinformatics.International journal of environmental research and public health · 2021Review
- Decreased Histone Acetylation Levels at Th1 and Regulatory Loci after Induction of Food Allergy.Nutrients · 2020Article
- The gut microbiota, environmental factors, and links to the development of food allergy.Clinical and molecular allergy : CMA · 2020Review
- Article
- Epigenetic dysregulation of naive CD4+ T-cell activation genes in childhood food allergy.Nature communications · 2018Article
- Review
- Milk's Role as an Epigenetic Regulator in Health and Disease.Diseases (Basel, Switzerland) · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCow's milk allergy (CMA) is a common disease in infancy. Early environmental factors are likely to contribute to CMA. It is known that epigenetic gene regulation can be altered by environmental factors. We have set up a proof of concept study, aiming to detect epigenetic associations specific with CMA.
methodsWe studied children from the Dutch EuroPrevall birth cohort study (N = 20 CMA, N = 23 controls, N = 10 tolerant boys), age and gender matched. CMA was challenge proven. Bisulfite converted DNA (blood) was analyzed using the 450K infinium DNA-methylation array. Four groups (combined, girls, boys and tolerant boys) were analysed between CMA and controls. Statistical analysis and pathway-analysis were performed in "R" using IMA, Minfi and the global-test package. Differentially methylated regions in DHX58, ZNF281, EIF42A and HTRA2 genes were validated by quantitative amplicon sequencing (ROCHE 454(®)).
resultsGeneral hypermethylation was found in the CMA group compared to control children, while this effect was absent in the tolerant group. Methylation differences were, among others, found in regions of DHX58, ZNF281, EIF42A and HTRA2 genes. Several of these genes are known to be involved in immunological pathways and associated with other allergies.
conclusionWe show that epigenetic associations are involved in CMA. Although, the statistical power of our study is limited and our sample was based on whole blood, we were still able to detect feasible loci and pathways. Therefore our findings might contribute to future diagnostic or therapeutic interventions for specific CMA. Further studies have to confirm the findings of our study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.