ArticleChemistry Central journal2016
Bioactivity-guided isolation of antioxidant and anti-hepatocarcinoma constituents from Veronica ciliata.
Article in Chemistry Central journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Chemical characterization of iridoid glycosides fromFrontiers in pharmacology · 2026Article
- Isolation of Volatile Compounds by Microwave-Assisted Extraction from SixPlants (Basel, Switzerland) · 2023Article
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- Rapidly screening of α-glucosidase inhibitors from Dioscorea opposita Thunb. peel based on rGO@FeJournal of enzyme inhibition and medicinal chemistry · 2018Article
- Active Fragment ofOxidative medicine and cellular longevity · 2017Article
- Iridoid Glycosides Fraction Isolated fromEvidence-based complementary and alternative medicine : eCAM · 2017Article
- HSCCC Separation of the Two Iridoid Glycosides and Three Phenolic Compounds from Veronica ciliata and Their in Vitro Antioxidant and Anti-Hepatocarcinoma Activities.Molecules (Basel, Switzerland) · 2016Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVeronica ciliata Fisch., widely distributed in western China, has been traditionally used in Tibetan Medicine as a treatment for hepatitis, cholecystitis, rheumatism, and urticaria. However, V. ciliata Fisch. has not been subjected to detailed chemical constitution analysis and the bioactive studies were restricted to its crude extracts. It is necessary to investigate the active chemical components of these extracts and identify their biological effects.
resultsFour iridoid glycosides, (veronicoside, cataposide, amphicoside, and verminoside) were isolated from the ethyl acetate fraction. Among these compounds, veronicoside and verminoside were isolated for the first time from this plant. These compounds exhibited strong antioxidant activity and inhibitory activity on HepG2 cell proliferation. The antioxidant activity of verminoside was equal to Vc. Cataposide, amphicoside and verminoside had stronger anti-hepatocarcinoma activity than 5-fluorouracil.
conclusionsFour iridoid glycosides,(veronicoside, cataposide, amphicoside and verminoside) were isolated from the extract of V. ciliata Fisch. using bioassay-guided screening.Among these compounds, veronicoside and verminoside were isolated for the first time from this plant. The above results indicated that these compounds were the active chemical components responsible for the antioxidant and anti-hepatocarcinoma properties of V. ciliata Fisch. The underlying mechanism of their bioactivity is worthy of further investigation. Graphical abstractBioactivity-guided isolation of antioxidant and anti-hepatocarcinoma constituents from Veronica ciliata.
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