ArticleInfectious agents and cancer2016
Prevalence of human papillomavirus types and variants and p16(INK4a) expression in head and neck squamous cells carcinomas in São Paulo, Brazil.
Article in Infectious agents and cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- miR-1-3p downregulation drives tumor invasion in oral squamous cell carcinoma: insights from in vitro, in vivo, and ex vivo models.Molecular biology reports · 2026Article
- Clinical profile and pattern of second primary tumors in HPV-positive and HPV-negative oropharyngeal cancer.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2026Article
- Cost-consequence analysis of surgical and clinical treatment modalities of laryngeal cancer.Clinics (Sao Paulo, Brazil) · 2025Article
- HPV16 Phylogenetic Variants in Anogenital and Head and Neck Cancers: State of the Art and Perspectives.Viruses · 2024Review
- p16Infectious agents and cancer · 2023Article
- Article
- Human papillomavirus prevalence in oral and oropharyngeal squamous cell carcinoma in South America: A systematic review and meta-analysis.Oncology reviews · 2022Article
- Exploring the roles of HPV16 variants in head and neck squamous cell carcinoma: current challenges and opportunities.Virology journal · 2021Review
- Correlation of p16 immunohistochemistry with clinical and epidemiological features in oropharyngeal squamous-cell carcinoma.PloS one · 2021Article
- Oral human papillomavirus prevalence and type distribution by country (Brazil, Mexico and the United States) and age among HPV infection in men study participants.International journal of cancer · 2020Article
- The contribution of Latin American research to HPV epidemiology and natural history knowledge.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020Review
- Immunometabolic Alterations by HPV Infection: New Dimensions to Head and Neck Cancer Disparity.Journal of the National Cancer Institute · 2019Review
- Human Papillomavirus Type 16International journal of medical sciences · 2019Article
- HPV infection and P16 expression in oral and oropharyngeal cancer in Kazakhstan.Infectious agents and cancer · 2018Article
- Human papillomavirus genome variants and head and neck cancers: a perspective.Infectious agents and cancer · 2018Review
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20 authors.
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Abstract
backgroundHuman papillomavirus (HPV) prevalence in head and neck squamous cell carcinomas (HNSCC) diverges geographically. The reliability of using p16(INK4a) expression as a marker of viral infection is controversial in HNSCC. We evaluated HPV types and HPV-16 variants prevalence, and p16(INK4a) expression in HNSCC specimens provided by two different Institutions in São Paulo.
methodsHPV DNA from formalin-fixed specimens was accessed by Inno-LiPA, HPV-16 variants by PCR-sequencing, and p16(INK4a) protein levels by immunohistochemistry.
resultsOverall, HPV DNA was detected among 19.4 % of the specimens (36/186). Viral prevalence was higher in the oral cavity (25.0 %, 23/92) then in other anatomical sites (oropharynx 14,3 %, larynx 13.7 %) when samples from both Institutions were analyzed together. HPV prevalence was also higher in the oral cavity when samples from both Institutions were analyzed separately. HPV-16 was the most prevalent type identified in 69.5 % of the HPV positive smaples and specimens were assigned into Asian-American (57.2 %) or European (42.8 %) phylogenetic branches. High expression of p16(INK4a) was more common among HPV positive tumors.
conclusionOur results support a role for HPV-16 in a subset of HNSCC.
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