ArticleFrontiers in plant science2016
Arabidopsis HIGH PLOIDY2 Sumoylates and Stabilizes Flowering Locus C through Its E3 Ligase Activity.
Article in Frontiers in plant science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Generation of viable hypomorphic and null mutant plants via CRISPR-Cas9 targeting mRNA splicing sites.Journal of plant research · 2025Article
- Research progress on delayed flowering under short-day condition inFrontiers in plant science · 2025Review
- HIGH PLOIDY2-mediated SUMOylation of transcription factor ARR1 controls two-component signaling in Arabidopsis.The Plant cell · 2024Article
- Highly sensitive site-specific SUMOylation proteomics in Arabidopsis.Nature plants · 2024Article
- E3 SUMO ligase SIZ1 splicing variants localize and function according to external conditions.Plant physiology · 2024Article
- A Tea Plant (International journal of molecular sciences · 2022Article
- Defects in meiotic chromosome segregation lead to unreduced male gametes in Arabidopsis SMC5/6 complex mutants.The Plant cell · 2021Article
- Phototropin Interactions with SUMO Proteins.Plant & cell physiology · 2021Article
- Ammonium-mediated reduction in salicylic acid content and recovery of plant growth in ArabidopsisPlant signaling & behavior · 2021Article
- Beyond the Genetic Pathways, Flowering Regulation Complexity inInternational journal of molecular sciences · 2021Review
- SUMO mediated regulation of transcription factors as a mechanism for transducing environmental cues into cellular signaling in plants.Cellular and molecular life sciences : CMLS · 2021Review
- Structural Maintenance of Chromosomes 5/6 Complex Is Necessary for Tetraploid Genome Stability inFrontiers in plant science · 2021Article
- An Insight into the Factors Influencing Specificity of the SUMO System in Plants.Plants (Basel, Switzerland) · 2020Review
- The SUMO E3 Ligase SIZ1 Negatively Regulates Shoot Regeneration.Plant physiology · 2020Article
- The SMC5/6 Complex Subunit NSE4A Is Involved in DNA Damage Repair and Seed Development.The Plant cell · 2019Article
- Nitrate Reductases Are Relocalized to the Nucleus by AtSIZ1 and Their Levels Are Negatively Regulated by COP1 and Ammonium.International journal of molecular sciences · 2018Article
- Review
- Sumoylation, Phosphorylation, and Acetylation Fine-Tune the Turnover of Plant Immunity Components Mediated by Ubiquitination.Frontiers in plant science · 2017Review
- SUMO E3 Ligases GmSIZ1a and GmSIZ1b regulate vegetative growth in soybean .Journal of integrative plant biology · 2017Article
- Winter Memory throughout the Plant Kingdom: Different Paths to Flowering.Plant physiology · 2017Review
Corrections and comments
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5 authors.
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Abstract
Flowering Locus C (FLC), a floral repressor, plays an important role in flowering. The mechanisms regulating FLC gene expression and protein function have been studied extensively; however, post-translational regulation of FLC remains unclear. Here, we identified Arabidopsis HIGH PLOIDY2 (HPY2) as an E3 SUMO ligase for FLC. In vitro and vivo pull-down assays showed that FLC physically interacts with HPY2. In vitro assays showed that the stimulation of FLC sumoylation by HPY2 was dependent on SUMO-activating enzyme E1 and -conjugating enzyme E2, indicating that HPY2 was an E3 SUMO ligase for FLC. In transgenic plants, inducible HPY2 overexpression increased the concentration of FLC, indicating that HPY2 stabilized FLC through direct sumoylation. Flowering time in hpy2-2 mutants was shorter than in wild-type plants under long- and short-day conditions, with a greater effect under short-day conditions, and FLC was downregulated in hpy2-2 mutants. These data indicate that HPY2 regulates FLC function and stability at both the transcriptional and post-translational levels through its E3 SUMO ligase activity.
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