ArticleFrontiers in plant science2016
ALA Inhibits ABA-induced Stomatal Closure via Reducing H2O2 and Ca(2+) Levels in Guard Cells.
Article in Frontiers in plant science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Hydrogen Peroxide: Its Role in Plant Biology and Crosstalk with Signalling Networks.International journal of molecular sciences · 2018Pooled it
- 5-Aminolevulinic acid improves strawberry salt tolerance through a NO-HJournal of advanced research · 2025Article
- Evaluate the physiological role of tetrapyrroles precursor on growth, yield and some biochemical composition of two cultivars of Vicia faba L.BMC plant biology · 2025Article
- Potential mechanisms for the rapid post-drought reversal of ABA-induced stomatal closure by melatonin, 5-aminolevulinic acid, and brassinosteroids.Photosynthetica · 2025Review
- ALA reverses ABA-induced stomatal closure by modulating PP2AC and SnRK2.6 activity in apple leaves.Horticulture research · 2023Article
- Abscisic acid increases hydrogen peroxide in mitochondria to facilitate stomatal closure.Plant physiology · 2023Article
- Drought and salinity stresses induced physio-biochemical changes in sugarcane: an overview of tolerance mechanism and mitigating approaches.Frontiers in plant science · 2023Review
- ALA induces stomatal opening through regulation among PTPA, PP2AC, and SnRK2.6.Frontiers in plant science · 2023Article
- Drought stress in 'Shine Muscat' grapevine: Consequences and a novel mitigation strategy-5-aminolevulinic acid.Frontiers in plant science · 2023Article
- Root Exposure to 5-Aminolevulinic Acid (ALA) Affects Leaf Element Accumulation, Isoprene Emission, Phytohormonal Balance, and Photosynthesis of Salt-StressedInternational journal of molecular sciences · 2022Article
- 5-Aminolevulinic Acid and 24-Epibrassinolide Improve the Drought Stress Resilience and Productivity of Banana Plants.Plants (Basel, Switzerland) · 2022Article
- The Transcription Factor MdERF78 Is Involved in ALA-Induced Anthocyanin Accumulation in Apples.Frontiers in plant science · 2022Article
- Distinct Roles for KASH Proteins SINE1 and SINE2 in Guard Cell Actin Reorganization, Calcium Oscillations, and Vacuolar Remodeling.Frontiers in plant science · 2022Article
- Article
- 5-aminolevulinic acid-mediated plant adaptive responses to abiotic stress.Plant cell reports · 2021Review
- A Role for Plant KASH Proteins in Regulating Stomatal Dynamics.Plant physiology · 2020Article
- 5-Aminolevulinic Acid Attenuates Atherosclerotic Plaque Progression in Low-Density Lipoprotein Receptor-Deficient Mice by Heme Oxygenase-1 Induction.Circulation reports · 2019Article
- Article
- Sugarcane Water Stress Tolerance Mechanisms and Its Implications on Developing Biotechnology Solutions.Frontiers in plant science · 2017Review
- ALA-Induced Flavonols Accumulation in Guard Cells Is Involved in Scavenging HFrontiers in plant science · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
5-Aminolevulinic acid (ALA), a newly proved natural plant growth regulator, is well known to improve plant photosynthesis under both normal and stressful conditions. However, its underlying mechanism remains largely unknown. Stomatal closure is one of the major limiting factors for photosynthesis and abscisic acid (ABA) is the most important hormone in provoking stomatal closing. Here, we showed that ALA significantly inhibited ABA-induced stomatal closure using wild-type and ALA-overproducing transgenic Arabidopsis (YHem1). We found that ALA decreased ABA-induced H2O2 and cytosolic Ca(2+) accumulation in guard cells with stomatal bioassay, laser-scanning confocal microscopy and pharmacological methods. The inhibitory effect of ALA on ABA-induced stomatal closure was similar to that of AsA (an important reducing substrate for H2O2 removal), CAT (a H2O2-scavenging enzyme), DPI (an inhibitor of the H2O2-generating NADPH oxidase), EGTA (a Ca-chelating agent), and AlCl3 (an inhibitor of calcium channel). Furthermore, ALA inhibited exogenous H2O2- or Ca(2+)-induced stomatal closure. Taken together, we conclude that ALA inhibits ABA-induced stomatal closure via reducing H2O2, probably by scavenging, and Ca(2+) levels in guard cells. Moreover, the inhibitive effect of ALA on ABA-induced stomatal closure was further confirmed in the whole plant. Finally, we demonstrated that ALA inhibits stomatal closing, but significantly improves plant drought tolerance. Our results provide valuable information for the promotion of plant production and development of a sustainable low-carbon society.
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