ReviewFrontiers in immunology2016
Roads Less Traveled: Sexual Dimorphism and Mast Cell Contributions to Migraine Pathology.
Review in Frontiers in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Giving Researchers a Headache - Sex and Gender Differences in Migraine.Frontiers in neurology · 2020Pooled it
- Article
- Review
- Trends in migraine incidence among women of childbearing age from 1990 to 2019 and the prediction for 2030: an analysis of national data in China.The journal of headache and pain · 2023Article
- Androgen receptor signaling protects male mice from the development of immune response to peanut.American journal of clinical and experimental immunology · 2023Article
- Xiongshao Zhitong Recipe Attenuates Nitroglycerin-Induced Migraine-Like BehaviorsFrontiers in pharmacology · 2022Article
- Involvement of Mast Cells in the Pathophysiology of Pain.Frontiers in cellular neuroscience · 2021Article
- RAR-related orphan receptor A: One gene with multiple functions related to migraine.CNS neuroscience & therapeutics · 2020Article
- Perinatal androgens organize sex differences in mast cells and attenuate anaphylaxis severity into adulthood.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Male and female sex hormones in primary headaches.The journal of headache and pain · 2018Review
- Pediatric abdominal migraine: current perspectives on a lesser known entity.Pediatric health, medicine and therapeutics · 2018Review
- The mouse cortical meninges are the site of immune responses to many different pathogens, and are accessible to intravital imaging.Methods (San Diego, Calif.) · 2017Review
- Gender-specific differences in the molecular signatures of adult Eosinophilic Oesophagitis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2017Article
- The Grand Challenge in Cranial Pain-From Migraine to Cranial Neuralgias: Understanding Differences and Similarities to Advance Knowledge and Management.Frontiers in neurology · 2017Article
- Repeated hapten exposure induces persistent tactile sensitivity in mice modeling localized provoked vulvodynia.PloS one · 2017Article
- Estrogen-Dependent Changes in Dura Mater Microvasculature Add New Insights to the Pathogenesis of Headache.Frontiers in neurology · 2017Review
- Sex-Specific Physiology and Cardiovascular Disease.Advances in experimental medicine and biologyReview
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Migraine is a common, little understood, and debilitating disease. It is much more prominent in women than in men (~2/3 are women) but the reasons for female preponderance are not clear. Migraineurs frequently experience severe comorbidities, such as allergies, depression, irritable bowel syndrome, and others; many of the comorbidities are more common in females. Current treatments for migraine are not gender specific, and rarely are migraine and its comorbidities considered and treated by the same specialist. Thus, migraine treatments represent a huge unmet medical need, which will only be addressed with greater understanding of its underlying pathophysiology. We discuss the current knowledge about sex differences in migraine and its comorbidities, and focus on the potential role of mast cells (MCs) in both. Sex-based differences in pain recognition and drug responses, fluid balance, and the blood-brain barrier are recognized but their impact on migraine is not well studied. Furthermore, MCs are well recognized for their prominent role in allergies but much less is known about their contributions to pain pathways in general and migraine specifically. MC-neuron bidirectional communication uniquely positions these cells as potential initiators and/or perpetuators of pain. MCs can secrete nociceptor sensitizing and activating agents, such as serotonin, prostaglandins, histamine, and proteolytic enzymes that can also activate the pain-mediating transient receptor potential vanilloid channels. MCs express receptors for both estrogen and progesterone that induce degranulation upon binding. Furthermore, environmental estrogens, such as Bisphenol A, activate MCs in preclinical models but their impact on pain pathways or migraine is understudied. We hope that this discussion will encourage scientists and physicians alike to bridge the knowledge gaps linking sex, MCs, and migraine to develop better, more comprehensive treatments for migraine patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.