ArticleFrontiers in pharmacology2016
In vivo Antihypertensive and Antihyperlipidemic Effects of the Crude Extracts and Fractions of Moringa stenopetala (Baker f.) Cufod. Leaves in Rats.
Article in Frontiers in pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Safety classification of herbal medicine use among hypertensive patients: a systematic review and meta-analysis.Frontiers in pharmacology · 2024Pooled it
- Facility-based prospective cohort study to evaluate Moringa stenopetala based diet consumption in management of diabetes and hypertension in South Ethiopia.Scientific reports · 2026Article
- Evaluation of the in vivo antidiabetic, in vitro antioxidant and alpha amylase inhibitory effects of Ocimum lamiifolium Hochst ex Benth leaf hydromethanolic crude extract in streptozotocin-induced diabetic mouse model.BMC complementary medicine and therapies · 2025Article
- Medicinal plants administered to control hypertension in Ethiopia: ethnomedicine, pharmacology, nutraceutical, phytochemistry, toxicology, and policy perspectives.Frontiers in cardiovascular medicine · 2025Review
- Traditional Herbal Remedies in the Management of Metabolic Disorders in Ethiopia: A Systematic Review of Ethnobotanical Studies and Pharmacological Activities.Evidence-based complementary and alternative medicine : eCAM · 2023Review
- Antidiabetic Activity of Hot Tea Infusion of Leaves ofJournal of experimental pharmacology · 2022Article
- Subchronic toxicity study of herbal tea ofToxicology reports · 2022Article
- Prenatal developmental toxicity study of herbal tea ofToxicology reports · 2022Article
- Evaluation of in vivo Antidiabetic, Antidyslipidemic and in vitro Anti-Oxidant Activity of Extract and Solvent Fractions ofJournal of experimental pharmacology · 2022Article
- Methanolic Crude Extract ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Evaluation of Antihyperglycemic Effect of Extract ofDiabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Evaluation ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Evaluation of Wound Healing Activity of Methanolic Crude Extract and Solvent Fractions of the Leaves ofJournal of experimental pharmacology · 2021Article
- Evaluation of Antidiabetic and Antioxidant Activity of Leaf Extract and Solvent Fractions ofJournal of experimental pharmacology · 2021Article
- Diet, Lifestyle and Cardiovascular Diseases: Linking Pathophysiology to Cardioprotective Effects of Natural Bioactive Compounds.International journal of environmental research and public health · 2020Review
- Antidiabetic and Anti-hyperlipidemic Effects of the Crude Hydromethanol Extract ofDiabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Hypoglycemic, Anti-Hyperglycemic and Anti-Hyperlipidemic Effects ofJournal of experimental pharmacology · 2020Article
- Article
- Review
- Diuretic activity of the aqueous crude extract and hot tea infusion ofJournal of experimental pharmacology · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMoringa stenopetala (Baker f.) Cufod. is a medicinal plant that has been used in Ethiopian traditional medicine as a remedy for treatment of hypertension and diabetes. The aim of this study was to evaluate antihypertensive and antihyperlipidemic effect in fructose induced hypertensive rats.
methodsRats were randomly divided into control and treatment groups (n = 6). Treatment groups were given daily extracts (250, 500, and 1000 mg/kg) orally with fructose. Whereas, positive, negative and normal control groups were received captopril (20 mg/kg/day with fructose), only fructose (66% w/v ad libitum) and distilled water ad libitum for 15 days, respectively. The blood pressure was measured every 5th day using tail cuff blood pressure analyzer, and on the 16th day the blood was sampled to evaluate antihyperlipidemic effect using clinical chemistry analyzer.
resultsThe study showed that aqueous and 70% ethanol extracts significantly prevented blood pressure increment in a dose dependent manner comparable to that of the standard drug. Similarly, the extracts suppressed increment in lipid profile (cholesterol, glucose, and triglycerides) compared with negative control. The biochemical test revealed that extracts produced a rise in liver but no effect on kidney function indicators compared with normal control.
conclusionThese findings revealed that both crude extracts of M. stenopetala (Baker f.) Cufod. possess antihypertensive and antihyperlipidemic effect.
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