ArticleFrontiers in synaptic neuroscience2016
Synaptic Vesicle Proteins and Active Zone Plasticity.
Article in Frontiers in synaptic neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Temporal Dynamics of Dorsal-Striatal Protein Networks During Radial-Arm Maze Training.Neuroinformatics · 2026Article
- Synaptic enrichment and dynamic regulation of the two opposing dopamine receptors within the same neurons.eLife · 2025Article
- Synaptotagmin-1 undergoes phase separation to regulate its calcium-sensitive oligomerization.The Journal of cell biology · 2024Article
- Focal clusters of peri-synaptic matrix contribute to activity-dependent plasticity and memory in mice.Cell reports · 2024Article
- Presynaptic regulators in memory formation.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Expansion microscopy in honeybee brains for high-resolution neuroanatomical analyses in social insects.Cell and tissue research · 2023Article
- Homeostatic synaptic plasticity rescues neural coding reliability.Nature communications · 2023Article
- Genetic regulation of central synapse formation and organization in Drosophila melanogaster.Genetics · 2022Review
- Glutamatergic Synapse Dysfunction inFrontiers in molecular neuroscience · 2022Article
- Identification of Rare Mutations of Two Presynaptic Cytomatrix GenesJournal of personalized medicine · 2021Article
- The glutamatergic synapse: a complex machinery for information processing.Cognitive neurodynamics · 2021Review
- Building a circuit through correlated spontaneous neuronal activity in the developing vertebrate and invertebrate visual systems.Genes & development · 2021Review
- Article
- HDAC6 in Diseases of Cognition and of Neurons.Cells · 2020Review
- Canonical Wnt Signaling Modulates the Expression of Pre- and Postsynaptic Components in Different Temporal Patterns.Molecular neurobiology · 2020Article
- Nanomachinery Organizing Release at Neuronal and Ribbon Synapses.International journal of molecular sciences · 2019Review
- Endogenous Tagging Reveals Differential Regulation of CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Mushroom Body Specific Transcriptome Analysis Reveals Dynamic Regulation of Learning and Memory Genes After Acquisition of Long-Term Courtship Memory inG3 (Bethesda, Md.) · 2018Article
- Postsynaptic Syntaxin 4 negatively regulates the efficiency of neurotransmitter release.Journal of neurogenetics · 2018Article
- Presynaptic active zones of mammalian neuromuscular junctions: Nanoarchitecture and selective impairments in aging.Neuroscience research · 2018Review
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Neurotransmitter is released from synaptic vesicles at the highly specialized presynaptic active zone (AZ). The complex molecular architecture of AZs mediates the speed, precision and plasticity of synaptic transmission. Importantly, structural and functional properties of AZs vary significantly, even for a given connection. Thus, there appear to be distinct AZ states, which fundamentally influence neuronal communication by controlling the positioning and release of synaptic vesicles. Vice versa, recent evidence has revealed that synaptic vesicle components also modulate organizational states of the AZ. The protein-rich cytomatrix at the active zone (CAZ) provides a structural platform for molecular interactions guiding vesicle exocytosis. Studies in Drosophila have now demonstrated that the vesicle proteins Synaptotagmin-1 (Syt1) and Rab3 also regulate glutamate release by shaping differentiation of the CAZ ultrastructure. We review these unexpected findings and discuss mechanistic interpretations of the reciprocal relationship between synaptic vesicles and AZ states, which has heretofore received little attention.
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