ArticleFrontiers in cellular neuroscience2016
General Anesthetic Conditions Induce Network Synchrony and Disrupt Sensory Processing in the Cortex.
Article in Frontiers in cellular neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Cellular and Microcircuit Mechanisms of Anesthetic Disruption of Conscious-State Organization.Cells · 2026Review
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- Dexmedetomidine Preserves Activity of Neurons in Primary Somatosensory Cortex Compared to Propofol and Ketamine.Brain sciences · 2022Article
- Reduced excitatory neuron activity and interneuron-type-specific deficits in a mouse model of Alzheimer's disease.Communications biology · 2022Article
- Large-scale waves of activity in the neonatal mouse brain in vivo occur almost exclusively during sleep cycles.Developmental neurobiology · 2022Article
- Functional states shape the spatiotemporal representation of local and cortex-wide neural activity in mouse sensory cortex.Journal of neurophysiology · 2022Article
- General anesthesia globally synchronizes activity selectively in layer 5 cortical pyramidal neurons.Neuron · 2022Article
- Propofol-induced Unresponsiveness Is Associated with a Brain Network Phase Transition.Anesthesiology · 2022Article
- Long-term dynamics of aberrant neuronal activity in awake Alzheimer's disease transgenic mice.Communications biology · 2021Article
- Versatile Surface Electrodes for Combined Electrophysiology and Two-Photon Imaging of the Mouse Central Nervous System.Frontiers in cellular neuroscience · 2021Article
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- State-Dependent Synchrony and Functional Connectivity in the Primary and Secondary Whisker Somatosensory Cortices.Frontiers in systems neuroscience · 2021Article
- Spatially confined responses of mouse visual cortex to intracortical magnetic stimulation from micro-coils.Journal of neural engineering · 2020Article
- Taste coding strategies in insular cortex.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- Audio-visual experience strengthens multisensory assemblies in adult mouse visual cortex.Nature communications · 2019Article
- Multisensory integration in rodent tactile but not visual thalamus.Scientific reports · 2018Article
- Timescales of Intrinsic BOLD Signal Dynamics and Functional Connectivity in Pharmacologic and Neuropathologic States of Unconsciousness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Cell Type Specific Representation of Vibro-tactile Stimuli in the Mouse Primary Somatosensory Cortex.Frontiers in neural circuits · 2018Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
General anesthetics are commonly used in animal models to study how sensory signals are represented in the brain. Here, we used two-photon (2P) calcium activity imaging with cellular resolution to investigate how neuronal activity in layer 2/3 of the mouse barrel cortex is modified under the influence of different concentrations of chemically distinct general anesthetics. Our results show that a high isoflurane dose induces synchrony in local neuronal networks and these cortical activity patterns closely resemble those observed in EEG recordings under deep anesthesia. Moreover, ketamine and urethane also induced similar activity patterns. While investigating the effects of deep isoflurane anesthesia on whisker and auditory evoked responses in the barrel cortex, we found that dedicated spatial regions for sensory signal processing become disrupted. We propose that our isoflurane-2P imaging paradigm can serve as an attractive model system to dissect cellular and molecular mechanisms that induce the anesthetic state, and it might also provide important insight into sleep-like brain states and consciousness.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.