Evidence map›Paper›PMID 27147819›Full record

ReviewIntegrative medicine insights2016

The Role of Vitamins in the Pathogenesis of Non-alcoholic Fatty Liver Disease.

Jiawei Li, Paul Cordero, Vi Nguyen, Jude A Oben

Open access · diamondAbstract readReview
In one paragraph

Review in Integrative medicine insights, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
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  17. Pirfenidone prevents and reverses hepatic insulin resistance and steatohepatitis by polarizing M2 macrophages.Laboratory investigation; a journal of technical methods and pathology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jiawei LiInstitute for Liver and Digestive Health, University College London, London, UK.
Paul CorderoInstitute for Liver and Digestive Health, University College London, London, UK.
Vi NguyenInstitute for Liver and Digestive Health, University College London, London, UK.; Department of Gastroenterology and Hepatology, Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK.
Jude A ObenInstitute for Liver and Digestive Health, University College London, London, UK.; Department of Gastroenterology and Hepatology, Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK.
University College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence of non-alcoholic fatty liver disease (NAFLD) is rising rapidly in parallel with obesity rates. The underlying pathogenesis of NAFLD remains an enigma but is largely influenced by individual lifestyle choices involving diet and exercise. Therefore, studies have highlighted the importance of calorie reduction and macronutrient composition (eg, carbohydrate and fat) in modifying disease outcomes. Micronutrients are also believed to play a role in disease progression. There are now an increasing number of studies linking vitamins with NAFLD, particularly vitamin E, and the supplementation of several different vitamins has been demonstrated as a promising therapeutic option in the treatment of NAFLD. This review provides a broad overview of the potential role of vitamins in NAFLD development and disease management.

Indexed as

fatty livermetabolic syndromemicronutrientoxidative stressvitamin

Identifiers

PMID27147819
PMCPMC4849418
OpenAlexW2344665524

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.