Evidence map›Paper›PMID 27147725›Full record

ArticleJournal of clinical microbiology2016

Laboratory Evaluation of a Point-of-Care Downward-Flow Assay for Simultaneous Detection of Antibodies to Treponema pallidum and Human Immunodeficiency Virus.

S Herbst de Cortina, C C Bristow, S K Vargas, D G Perez, K A Konda, C F Caceres, J D Klausner

Open access · bronzeAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Point-of-Care Diagnostics for Diagnosis of Active Syphilis Infection: Needs, Challenges and the Way Forward.International journal of environmental research and public health · 2022
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. An Update on the Global Epidemiology of Syphilis.Current epidemiology reports · 2018
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

S Herbst de CortinaDivision of Infectious Diseases, Department of Medicine, University of California Los Angeles, Los Angeles, California, USA sherbstdecortina@mednet.ucla.edu.
C C BristowDivision of Global Public Health, Department of Medicine, University of California San Diego, La Jolla, California, USA.
S K VargasUnit of Health, Sexuality, and Human Development, and Laboratory of Sexual Health, Universidad Peruana Cayetano Heredia, Miraflores, Lima, Peru.
D G PerezUnit of Health, Sexuality, and Human Development, and Laboratory of Sexual Health, Universidad Peruana Cayetano Heredia, Miraflores, Lima, Peru.
K A KondaDivision of Infectious Diseases, Department of Medicine, University of California Los Angeles, Los Angeles, California, USA.
C F CaceresUnit of Health, Sexuality, and Human Development, and Laboratory of Sexual Health, Universidad Peruana Cayetano Heredia, Miraflores, Lima, Peru.
J D KlausnerDivision of Infectious Diseases, Department of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Universidad Peruana Cayetano Heredia · PEUniversity of California, Los Angeles · USUniversity of California, San Diego · US

Funding

Training Program in Substance Use, HIV and Related InfectionsT32DA023356 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Natasha Martin, Steffanie A Strathdee · 2007 to 2026
$7.8M
Syphilis: Translating technology to understand a neglected epidemicR01AI099727 · NIAID · UNIVERSIDAD PERUANA CAYETANO HEREDIA · PI CACERES, CARLOS F. · 2012 to 2016
$1.1M
NIAID NIH HHS R01 AI099727NIDA NIH HHS T32 DA023356
6 · The paper itself

Abstract

Combining the detection of syphilis and HIV antibodies into one point-of-care test integrates syphilis screening into already existing HIV screening programs, which may be particularly beneficial in settings such as antenatal care. Using the INSTI Multiplex downward-flow immunoassay, we tested 200 stored serum samples from high-risk patients enrolled in a longitudinal study on HIV infection and syphilis in Peruvian men who have sex with men and transgender women. This rapid assay detected HIV and Treponema pallidum serum antibodies with sensitivities of 100% (95% confidence interval [CI], 95.9% to 100%) and 87.4% (95% CI, 81.4% to 92.0%), respectively, and specificities of 95.5% (95% CI, 89.9% to 98.5%) and 97.0% (95% CI, 84.2% to 99.9%), respectively (n = 200). The sensitivity for syphilis antibody detection was higher in patients with a rapid plasma reagin titer of ≥1:8 (97.3%) than in those with a titer of ≤1:4 (90%) or a nonreactive titer (66.7%).

Indexed as

Point-of-Care SystemsAntibodies, BacterialClinical Laboratory TechniquesFemaleHIVHIV AntibodiesHIV InfectionsHumansImmunoassayLongitudinal StudiesMalePeruSensitivity and SpecificitySyphilisTransgender PersonsTreponema pallidumAntibodies, BacterialHIV Antibodies

Identifiers

PMID27147725
PMCPMC4922097
OpenAlexW2346226431

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.