ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2016
On the Role of the Pedunculopontine Nucleus and Mesencephalic Reticular Formation in Locomotion in Nonhuman Primates.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Cell-type specific sensory and motor activity in the cuneiform nucleus and pedunculopontine nucleus in mice.Scientific reports · 2025Article
- Pedunculopontine-stimulation obstructs hippocampal theta rhythm and halts movement.Scientific reports · 2025Article
- The relation of eye movements to the occurrence of freezing of gait in Parkinson's disease.Brain communications · 2025Article
- The Mesencephalic Locomotor Region: Multiple Cell Types, Multiple Behavioral Roles, and Multiple Implications for Disease.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Functional contribution of mesencephalic locomotor region nuclei to locomotor recovery after spinal cord injury.Cell reports. Medicine · 2023Article
- Spatiotemporal scaling changes in gait in a progressive model of Parkinson's disease.Frontiers in neurology · 2022Article
- Functional MRI Reveals Locomotion-Control Neural Circuits in Human Brainstem.Brain sciences · 2020Article
- Anatomical Characterization of the Human Structural Connectivity between the Pedunculopontine Nucleus and Globus Pallidus via Multi-Shell Multi-Tissue Tractography.Medicina (Kaunas, Lithuania) · 2020Article
- Activation of Brainstem Neurons During Mesencephalic Locomotor Region-Evoked Locomotion in the Cat.Frontiers in systems neuroscience · 2019Article
- Targeting the pedunculopontine nucleus in Parkinson's disease: Time to go back to the drawing board.Movement disorders : official journal of the Movement Disorder Society · 2018Review
- Relating structural and functional brainstem connectivity to disease measures in epilepsy.Neurology · 2018Article
- Role of the pedunculopontine nucleus in controlling gait and sleep in normal and parkinsonian monkeys.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Dynamic cortical participation during bilateral, cyclical ankle movements: Effects of Parkinson's disease.PloS one · 2018Article
- Nigral Glutamatergic Neurons Control the Speed of Locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- A Brainstem-Spinal Cord Inhibitory Circuit for Mechanical Pain Modulation by GABA and Enkephalins.Neuron · 2017Article
- Monoamine Release in the Cat Lumbar Spinal Cord during Fictive Locomotion Evoked by the Mesencephalic Locomotor Region.Frontiers in neural circuits · 2017Article
- Dopamine and the Brainstem Locomotor Networks: From Lamprey to Human.Frontiers in neuroscience · 2017Review
- Recording Gamma Band Oscillations in Pedunculopontine Nucleus Neurons.Journal of visualized experiments : JoVE · 2016Article
- The primate pedunculopontine nucleus region: towards a dual role in locomotion and waking state.Journal of neural transmission (Vienna, Austria : 1996) · 2016Article
- Implications of gamma band activity in the pedunculopontine nucleus.Journal of neural transmission (Vienna, Austria : 1996) · 2016Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledThe mesencephalic reticular formation (MRF) is formed by the pedunculopontine and cuneiform nuclei, two neuronal structures thought to be key elements in the supraspinal control of locomotion, muscle tone, waking, and REM sleep. The role of MRF has also been advocated in modulation of state of arousal leading to transition from wakefulness to sleep and it is further considered to be a main player in the pathophysiology of gait disorders seen in Parkinson's disease. However, the existence of a mesencephalic locomotor region and of an arousal center has not yet been demonstrated in primates. Here, we provide the first extensive electrophysiological mapping of the MRF using extracellular recordings at rest and during locomotion in a nonhuman primate (NHP) (Macaca fascicularis) model of bipedal locomotion. We found different neuronal populations that discharged according to a phasic or a tonic mode in response to locomotion, supporting the existence of a locomotor neuronal circuit within these MRF in behaving primates. Altogether, these data constitute the first electrophysiological characterization of a locomotor neuronal system present within the MRF in behaving NHPs under normal conditions, in accordance with several studies done in different experimental animal models. SIGNIFICANCE STATEMENT: We provide the first extensive electrophysiological mapping of the two major components of the mesencephalic reticular formation (MRF), namely the pedunculopontine and cuneiform nuclei. We exploited a nonhuman primate (NHP) model of bipedal locomotion with extracellular recordings in behaving NHPs at rest and during locomotion. Different MRF neuronal groups were found to respond to locomotion, with phasic or tonic patterns of response. These data constitute the first electrophysiological evidences of a locomotor neuronal system within the MRF in behaving NHPs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.