Evidence map›Paper›PMID 27147629›Full record

ArticleBMJ case reports2016

Fatal disseminated varicella zoster infection following zoster vaccination in an immunocompromised patient.

E Costa, J Buxton, J Brown, K E Templeton, J Breuer, I Johannessen

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Vaccination of Adults With Cancer: ASCO Guideline.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Guideline
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  14. Can Immunocompetence Be Restored in Chronic Lymphocytic Leukemia?Hematology/oncology clinics of North America · 2021
    Review
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  16. Observational
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

E CostaRoyal Infirmary of Edinburgh, Edinburgh, UK.
J BuxtonBorders General Hospital, Melrose, UK.
J BrownGreat Ormond St Hospital for Children, London, UK.
K E TempletonDepartment of Medical Virology, Royal Infirmary of Edinburgh, Edinburgh, UK.
J BreuerGreat Ormond St Hospital for Children, London, UK.
I JohannessenRoyal Infirmary of Edinburgh, Edinburgh, UK.
Edinburgh Royal Infirmary · GBBorders General Hospital · GBGreat Ormond Street Hospital · GBUniversity College London · GB

Funding

Medical Research Council G0700814
6 · The paper itself

Abstract

A 79-year-old man with chronic lymphocytic leukaemia presented with fever and a widespread vesicular rash on 19 November 2014. The patient had not been under immunosuppressive regime for 6 months. He had received a shingles vaccine on 14th October and developed flu-like symptoms after 2 weeks. Intravenous antimicrobial therapy including aciclovir was started. He remained stable with no evidence of systemic involvement. On day 5, he developed respiratory and renal failure that required transfer to intensive care unit. Vesicle fluid, bronchoalveolar lavage and plasma were positive for varicella zoster virus by PCR. Slight clinical improvement allowed extubation on day 16. He subsequently deteriorated and died on day 25. Multiorgan failure was considered the immediate cause of death whereas disseminated varicella zoster infection was stated in the medical certificate as the other condition leading to this outcome. Varicella zoster Oka vaccine strain was detected in vesicle fluid, using PCR.

Indexed as

AcyclovirAgedFatal OutcomeHerpes ZosterHerpes Zoster VaccineHumansLeukemia, Lymphocytic, Chronic, B-CellMaleRenal InsufficiencyRespiratory InsufficiencyAcyclovirHerpes Zoster Vaccine

Identifiers

PMID27147629
PMCPMC4885517
OpenAlexW2208214158

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.