ArticleOncotarget2016
Increased number of negative lymph nodes is associated with improved survival outcome in node positive gastric cancer following radical gastrectomy.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Deep learning-based prediction of lymph node metastasis and occult tumor cells in gastric cancer using histopathological images: a retrospective study.British journal of cancer · 2026Article
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- Prognostic factors of advanced gastric cancer.Journal of the Chinese Medical Association : JCMA · 2021Article
- Impact of the extent of negative lymph nodes in gastric adenocarcinoma undergoing primary surgical resection: An institutional report.Journal of the Chinese Medical Association : JCMA · 2021Article
- Short-term outcomes of laparoscopic versus open total gastrectomy after neoadjuvant chemotherapy: a cohort study using the propensity score matching method.Journal of gastrointestinal oncology · 2021Article
- The impact of negative lymph nodes in the survival outcomes of pN+ patients following radical gastrectomy: the inverse lymph node ratio as a better score to study negative lymph nodes.Updates in surgery · 2020Article
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- Does Lymphadenectomy with at Least 15 Perigastric Lymph Nodes Retrieval Promise an Improved Survival for Gastric Cancer: A Retrospective Cohort Study in Southern China.Journal of Cancer · 2019Article
- Effect of lymph nodes count in node-positive gastric cancer.Journal of Cancer · 2019Article
- The prognostic value of negative lymph node count for patients with cervical cancer after radical surgery.Oncotarget · 2018Article
- Prognostic value of number of negative lymph node in patients with stage II and IIIa non-small cell lung cancer.Oncotarget · 2017Article
- Negative lymph node count is a significant prognostic factor in patient with stage IV gastric cancer after palliative gastrectomy.Oncotarget · 2017Article
- The prognostic value of negative lymph node count for patients with gastric cancer who received preoperative radiotherapy.Oncotarget · 2017Article
- Negative lymph node count is an independent prognostic factor for patients with rectal cancer who received preoperative radiotherapy.BMC cancer · 2017Article
- Establishment and Validation of a Nomogram Based on Negative Lymph Nodes to Predict Survival in Postoperative Patients with non-Small Cell Lung Cancer.Technology in cancer research & treatmentArticle
- Influence of the coronavirus disease 2019 pandemic on gastric cancer: associations with diagnostic delays, clinicopathological features, and 3-year survival.Annals of Saudi medicineArticle
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The concept of negative lymph node (NLN) counts has recently attracted attention as a prognostic indicator in various cancer. However, the correlation between NLN counts and patient prognosis in the setting of gastric cancer is not fully studied. Surveillance, Epidemiology, and End Results Program (SEER)-registered gastric cancer patients were used for analysis in this study. Clinicopathological characteristics, including race, age, gender, and tumor stage, grade, and cause specific survival were collected. Univariate and multivariate Cox proportional hazards model were used to assess the risk factors for survival. As results, X-tile plots identified 3 and 9 as the optimal cutoff value to divide the patients into high, middle and low risk subsets in terms of cause specific survival, and NLN was validated as independently prognostic factor in mulivariate Cox analysis (P < 0.001). Further analysis showed that NLN was a prognosis factor in each N stage. Collectively, our study results firmly demonstrated that the number of NLNs was an independent prognostic factor for gastric cancer patients, and together with the N stage, it could provide more accurate prognostic information than the N stage alone.
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