ArticleJournal of the American Society of Nephrology : JASN2016
Filgrastim-Induced Crescentic Transformation of Recurrent IgG2λ GN.
Article in Journal of the American Society of Nephrology : JASN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ascertaining the mechanistic etiology of COVID-associated glomerulonephritis: a systematic review.Frontiers in medicine · 2025Pooled it
- Crescentic transformation induced by granulocyte-colony stimulating factor administration-a case report and review of the literature.Clinical kidney journal · 2026Article
- Paraneoplastic Syndrome After Kidney Transplantation: Frequency, Risk Factors, Differences to Paraneoplastic Occurrence of Glomerulonephritis in the Native Kidney, and Implications on Long-Term Kidney Graft Function.Transplant international : official journal of the European Society for Organ Transplantation · 2024Review
- IgA nephropathy diagnosed as a result of acute exacerbation due to G-CSF administration.CEN case reports · 2023Article
- Proliferative glomerulonephritis with monoclonal IgG deposits triggered by Filgrastim in a patient with multiple myeloma.Journal of nephrology · 2023Article
- G-CSF-induced ANCA associated glomerulonephritis in the presence of silent membranous "full house nephropathy" in an altruistic bone marrow donor.Renal failure · 2022Article
- Article
- Filgrastim-induced recurrent macroscopic hematuria in a patient with DNAJB9 positive fibrillary glomerulonephritis.Journal of nephrology · 2022Article
- A Fresh Perspective on Monoclonal Gammopathies of Renal Significance.Kidney international reports · 2021Review
- Kidney Biopsy Findings in Patients with COVID-19.Journal of the American Society of Nephrology : JASN · 2020Article
- Article
- Clinicopathological analysis of proliferative glomerulonephritis with monoclonal IgG deposits in 5 renal allografts.BMC nephrology · 2018Article
- Evolution of Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits Over a Decade.Indian journal of nephrologyArticle
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proliferative GN with monoclonal IgG deposits is an increasingly recognized form of GN, but its relation to hematologic malignancy remains poorly understood. Filgrastim, an analog for granulocyte colony-stimulating factor produced by recombinant DNA technology, is frequently used to stimulate bone marrow release of hematopoietic progenitor cells in preparation for stem cell transplant. We report an exceptional case of proliferative GN with monoclonal IgG2λ deposits in a young man whose disease progressed slowly to CKD, which was followed by a preemptive kidney transplant. The patient developed recurrent GN in the allograft and clinically detectable plasma cell neoplasm 9 years after the first renal manifestations. Contemporaneous with filgrastim administration for stem cell mobilization, the patient's slowly progressive GN underwent severe crescentic transformation, leading to rapidly progressive and irreversible allograft failure. This report explores the spectrum of GN with monoclonal IgG deposits and the pathophysiologic role of granulocyte colony-stimulating factor in exacerbation of preexisting GN.
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