Evidence map›Paper›PMID 27147324›Full record

ArticleMedical physics2016

Photon-counting hexagonal pixel array CdTe detector: Spatial resolution characteristics for image-guided interventional applications.

Srinivasan Vedantham, Suman Shrestha, Andrew Karellas, Linxi Shi, Matthew J Gounis, Ronaldo Bellazzini, Gloria Spandre, Alessandro Brez, Massimo Minuti

Abstract read
In one paragraph

Article in Medical physics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Emerging Breast Imaging Technologies on the Horizon.Seminars in ultrasound, CT, and MR · 2018
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Srinivasan VedanthamDepartment of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655.
Suman ShresthaDepartment of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655.
Andrew KarellasDepartment of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655.
Linxi ShiDepartment of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655.
Matthew J GounisDepartment of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655.
Ronaldo BellazziniIstituto Nazionale di Fisica Nucleare (INFN), Pisa 56127, Italy and Pixirad Imaging Counters s.r.l., L. Pontecorvo 3, Pisa 56127, Italy.
Gloria SpandreIstituto Nazionale di Fisica Nucleare (INFN), Pisa 56127, Italy and Pixirad Imaging Counters s.r.l., L. Pontecorvo 3, Pisa 56127, Italy.
Alessandro BrezIstituto Nazionale di Fisica Nucleare (INFN), Pisa 56127, Italy and Pixirad Imaging Counters s.r.l., L. Pontecorvo 3, Pisa 56127, Italy.
Massimo MinutiIstituto Nazionale di Fisica Nucleare (INFN), Pisa 56127, Italy and Pixirad Imaging Counters s.r.l., L. Pontecorvo 3, Pisa 56127, Italy.
University of Massachusetts Chan Medical School · USIstituto Nazionale di Fisica Nucleare, Sezione di Pisa · IT

Funding

Reducing mastectomy rates in invasive lobular carcinoma by high-resolution 3D breast CTR01CA195512 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI VEDANTHAM, SRINIVASAN · 2015 to 2017
$757k
NCI NIH HHS R01 CA195512
6 · The paper itself

Abstract

purposeHigh-resolution, photon-counting, energy-resolved detector with fast-framing capability can facilitate simultaneous acquisition of precontrast and postcontrast images for subtraction angiography without pixel registration artifacts and can facilitate high-resolution real-time imaging during image-guided interventions. Hence, this study was conducted to determine the spatial resolution characteristics of a hexagonal pixel array photon-counting cadmium telluride (CdTe) detector.

methodsA 650 μm thick CdTe Schottky photon-counting detector capable of concurrently acquiring up to two energy-windowed images was operated in a single energy-window mode to include photons of 10 keV or higher. The detector had hexagonal pixels with apothem of 30 μm resulting in pixel pitch of 60 and 51.96 μm along the two orthogonal directions. The detector was characterized at IEC-RQA5 spectral conditions. Linear response of the detector was determined over the air kerma rate relevant to image-guided interventional procedures ranging from 1.3 nGy/frame to 91.4 μGy/frame. Presampled modulation transfer was determined using a tungsten edge test device. The edge-spread function and the finely sampled line spread function accounted for hexagonal sampling, from which the presampled modulation transfer function (MTF) was determined. Since detectors with hexagonal pixels require resampling to square pixels for distortion-free display, the optimal square pixel size was determined by minimizing the root-mean-squared-error of the aperture functions for the square and hexagonal pixels up to the Nyquist limit.

resultsAt Nyquist frequencies of 8.33 and 9.62 cycles/mm along the apothem and orthogonal to the apothem directions, the modulation factors were 0.397 and 0.228, respectively. For the corresponding axis, the limiting resolution defined as 10% MTF occurred at 13.3 and 12 cycles/mm, respectively. Evaluation of the aperture functions yielded an optimal square pixel size of 54 μm. After resampling to 54 μm square pixels using trilinear interpolation, the presampled MTF at Nyquist frequency of 9.26 cycles/mm was 0.29 and 0.24 along the orthogonal directions and the limiting resolution (10% MTF) occurred at approximately 12 cycles/mm. Visual analysis of a bar pattern image showed the ability to resolve close to 12 line-pairs/mm and qualitative evaluation of a neurovascular nitinol-stent showed the ability to visualize its struts at clinically relevant conditions.

conclusionsHexagonal pixel array photon-counting CdTe detector provides high spatial resolution in single-photon counting mode. After resampling to optimal square pixel size for distortion-free display, the spatial resolution is preserved. The dual-energy capabilities of the detector could allow for artifact-free subtraction angiography and basis material decomposition. The proposed high-resolution photon-counting detector with energy-resolving capability can be of importance for several image-guided interventional procedures as well as for pediatric applications.

Indexed as

Cadmium CompoundsPhotonsTelluriumAlloysAngiography, Digital SubtractionBlood VesselsFingersHumansLinear ModelsModels, AnatomicPhantoms, ImagingPolymethyl MethacrylateRadiometryStentsTherapy, Computer-AssistedWristAlloysCadmium Compoundscadmium telluridenitinolPolymethyl MethacrylateTellurium

Identifiers

PMID27147324
PMCPMC4826388
OpenAlexW2315081024

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.