ArticleNature2016
Unique human immune signature of Ebola virus disease in Guinea.
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Article in Nature, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers, 1 of them a synthesis that pooled it.
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132citing papers in PubMed, 1 pooled it
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Who cites it
132 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of the immuno-inflammatory dysfunction secondary to viral hemorrhagic fevers; Ebola and Lassa fever.PLoS neglected tropical diseases · 2025Pooled it
- Improved VSV-Ebola-GP booster vaccination approach promotes antibody affinity maturation and durable anti-Ebola immunity in humans.Nature immunology · 2026Trial
- Ebola virus and Sudan virus infection in humans: a comparison to inform vaccine research and development.Emerging microbes & infections · 2026Review
- Molecular Phenotypes of Sex- and Age-Specific Differences Relating to Outcome in Patients With Ebola Virus Disease.The Journal of infectious diseases · 2026Article
- Identification of Host Gene Transcripts by Machine Learning and Their Application to Predict Outcome in Ebola Virus Disease.The Journal of infectious diseases · 2026Article
- CD4Nature immunology · 2026Article
- Low-dose VSV-EBOV vaccination provides rapid protection from lethal Ebola virus challenge.bioRxiv : the preprint server for biology · 2026Article
- Delayed type I interferon response and the subsequent out-of-sequence cytokine signal inhibit T cell induction in non-surviving Ebola virus-infected patients.Frontiers in immunology · 2026Article
- Discovery of a pre-vein progenitor that requires VEGF/ERK inhibition to complete vein differentiation.bioRxiv : the preprint server for biology · 2025Article
- Cellular immunophenotyping in human and primate tissues during healthy conditions and Ebola and Nipah infections.JCI insight · 2025Article
- Antibody-Based Antigen Delivery to Dendritic Cells as a Vaccination Strategy Against Ebola Virus Disease.The Journal of infectious diseases · 2025Article
- Expansion of myeloid suppressor cells and suppression of Lassa virus-specific T cells during fatal Lassa fever.PLoS pathogens · 2025Article
- Vascular dysfunction in hemorrhagic viral fevers: opportunities for organotypic modeling.Biofabrication · 2024Review
- Serum Concentrations of TIM-3, LAG-3, and PD-1 in Patients with Hemorrhagic Fever with Renal Syndrome.Life (Basel, Switzerland) · 2024Article
- Inhibition of SFTSV replication in humanized mice by a subcutaneously administered anti-PD1 nanobody.EMBO molecular medicine · 2024Article
- Autoimmunity-associated allele of tyrosine phosphatase gene PTPN22 enhances anti-viral immunity.PLoS pathogens · 2024Article
- Impact of the immune profiles of hypertensive patients with and without obesity on COVID-19 severity.International journal of obesity (2005) · 2024Article
- Interplay of Ebola Virus With Immune Cells Leading to Their Death by Diverse Mechanisms.The Journal of infectious diseases · 2023Article
- Ebola virus shed glycoprotein is toxic to human T, B, and natural killer lymphocytes.iScience · 2023Article
- Dysregulated IFN-γ signals promote autoimmunity in STAT1 gain-of-function syndrome.Science translational medicine · 2023Article
72 more citing papers are in PubMed but not listed here.
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Authors and funding
87 authors.
Paula RuibalHeinrich Pette Institute, Leibniz Institute for Experimental Virology, 20251 Hamburg, Germany.
Lisa OestereichBernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, 20359 Hamburg, Germany.
Anja LüdtkeHeinrich Pette Institute, Leibniz Institute for Experimental Virology, 20251 Hamburg, Germany.
Beate Becker-ZiajaBernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, 20359 Hamburg, Germany.
David M WozniakBernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, 20359 Hamburg, Germany.
Romy KerberBernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, 20359 Hamburg, Germany.
Miša KorvaEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Mar Cabeza-CabrerizoBernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, 20359 Hamburg, Germany.
Joseph A BoreEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Fara Raymond KoundounoEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Sophie DuraffourBernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, 20359 Hamburg, Germany.
Romy WellerEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Anja ThorenzEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Eleonora CiminiEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Domenico ViolaEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Chiara AgratiEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Johanna RepitsEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Babak AfroughEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Lauren A CowleyEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Didier NgaboEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Julia HinzmannEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Marc MertensEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Inês VitorianoEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Christopher H LogueEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Jan Peter BoettcherEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Elisa PallaschBernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, 20359 Hamburg, Germany.
Andreas SachseEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Amadou BahEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Katja NitzscheGerman Center for Infection Research (DZIF), Partner Sites Hamburg, Munich, and Marburg, Germany.
Eeva KuismaEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Janine MichelEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Tobias HolmBernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, 20359 Hamburg, Germany.
Elsa-Gayle ZekengEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Isabel García-DorivalEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Roman WölfelGerman Center for Infection Research (DZIF), Partner Sites Hamburg, Munich, and Marburg, Germany.
Kilian StoeckerGerman Center for Infection Research (DZIF), Partner Sites Hamburg, Munich, and Marburg, Germany.
Erna FleischmannGerman Center for Infection Research (DZIF), Partner Sites Hamburg, Munich, and Marburg, Germany.
Thomas StreckerGerman Center for Infection Research (DZIF), Partner Sites Hamburg, Munich, and Marburg, Germany.
Antonino Di CaroEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Tatjana Avšič-ŽupancEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Andreas KurthEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Silvia MeschiEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Stephane MélyEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Edmund NewmanEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Anne BocquinEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Zoltan KisEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Anne KelterbaumGerman Center for Infection Research (DZIF), Partner Sites Hamburg, Munich, and Marburg, Germany.
Peter MolkenthinGerman Center for Infection Research (DZIF), Partner Sites Hamburg, Munich, and Marburg, Germany.
Fabrizio CarlettiEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Jasmine PortmannEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Svenja WolffGerman Center for Infection Research (DZIF), Partner Sites Hamburg, Munich, and Marburg, Germany.
Concetta CastillettiEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Gordian SchudtGerman Center for Infection Research (DZIF), Partner Sites Hamburg, Munich, and Marburg, Germany.
Alexandra FizetEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Lisa J OttowellEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Eva HerkerHeinrich Pette Institute, Leibniz Institute for Experimental Virology, 20251 Hamburg, Germany.
Thomas JacobsBernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, 20359 Hamburg, Germany.
Birte KretschmerEurice, European Research and Project Office, 10115 Berlin, Germany.
Ettore SeveriEuropean Centre for Disease Prevention and Control, 171 65 Solna, Sweden.
Nobila OuedraogoRobert Koch Institute, 13353 Berlin, Germany.
Mar LagoInfectious Diseases Unit, Internal Medicine Service, Hospital La Paz, 28046 Madrid, Spain.
Anabel NegredoNational Center of Microbiology, Institute of Health 'Carlos III', 28220 Madrid, Spain.
Leticia FrancoNational Center of Microbiology, Institute of Health 'Carlos III', 28220 Madrid, Spain.
Pedro AndaNational Center of Microbiology, Institute of Health 'Carlos III', 28220 Madrid, Spain.
Stefan SchmiedelUniversity Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Benno KreuelsBernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, 20359 Hamburg, Germany.
Dominic WichmannGerman Center for Infection Research (DZIF), Partner Sites Hamburg, Munich, and Marburg, Germany.
Marylyn M AddoGerman Center for Infection Research (DZIF), Partner Sites Hamburg, Munich, and Marburg, Germany.
Ansgar W LohseGerman Center for Infection Research (DZIF), Partner Sites Hamburg, Munich, and Marburg, Germany.
Hilde De ClerckMédecins sans Frontières, B-1050 Brussels, Belgium.
Carolina NanclaresMédecins sans Frontières, B-1050 Brussels, Belgium.
Sylvie JonckheereMédecins sans Frontières, B-1050 Brussels, Belgium.
Michel Van HerpMédecins sans Frontières, B-1050 Brussels, Belgium.
Armand SprecherMédecins sans Frontières, B-1050 Brussels, Belgium.
Gao XiaojiangCancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA.
Mary CarringtonCancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA.
Osvaldo MirandaHospital Militar Central Dr. Carlos J. Finlay, 11400 Havana, Cuba.
Carlos M CastroHospital Militar Central Dr. Carlos J. Finlay, 11400 Havana, Cuba.
Martin GabrielBernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, 20359 Hamburg, Germany.
Patrick DruryWorld Health Organization, 1211 Geneva 27, Switzerland.
Pierre FormentyWorld Health Organization, 1211 Geneva 27, Switzerland.
Boubacar DialloWorld Health Organization, 1211 Geneva 27, Switzerland.
Lamine KoivoguiInstitut National de Santé Publique, 2101 Conakry, Guinea.
N'Faly MagassoubaUniversité Gamal Abdel Nasser de Conakry, CHU Donka, 2101 Conakry, Guinea.
Miles W CarrollEuropean Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Stephan GüntherBernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, 20359 Hamburg, Germany.
César Muñoz-FontelaHeinrich Pette Institute, Leibniz Institute for Experimental Virology, 20251 Hamburg, Germany.
Funding
Effects of genetic polymorphism in MHC, KIR, and related loci on human diseaseZIABC010791 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CARRINGTON, MARY N. · 2009 to 2025
$18.2MMolecular genetics and population studies of the KIR and HLA gene complexesZIABC010792 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CARRINGTON, MARY N. · 2009 to 2025
$7.8MEffects of genetic polymorphism in the MHC, KIR, and related loci on human diseaZ01BC010791 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CARRINGTON, MARY N. · 2007 to 2008
$2.4MMolecular genetics and population studies of the KIR and HLA gene complexesZ01BC010792 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CARRINGTON, MARY N. · 2007 to 2008
$1.0MCCR NIH HHS HHSN261200800001CIntramural NIH HHS Z01 BC010791Intramural NIH HHS Z01 BC010792NCI NIH HHS HHSN261200800001E
Abstract
Despite the magnitude of the Ebola virus disease (EVD) outbreak in West Africa, there is still a fundamental lack of knowledge about the pathophysiology of EVD. In particular, very little is known about human immune responses to Ebola virus. Here we evaluate the physiology of the human T cell immune response in EVD patients at the time of admission to the Ebola Treatment Center in Guinea, and longitudinally until discharge or death. Through the use of multiparametric flow cytometry established by the European Mobile Laboratory in the field, we identify an immune signature that is unique in EVD fatalities. Fatal EVD was characterized by a high percentage of CD4(+) and CD8(+) T cells expressing the inhibitory molecules CTLA-4 and PD-1, which correlated with elevated inflammatory markers and high virus load. Conversely, surviving individuals showed significantly lower expression of CTLA-4 and PD-1 as well as lower inflammation, despite comparable overall T cell activation. Concomitant with virus clearance, survivors mounted a robust Ebola-virus-specific T cell response. Our findings suggest that dysregulation of the T cell response is a key component of EVD pathophysiology.
Indexed as
CTLA-4 AntigenEbolavirusFemaleFlow CytometryGuineaHemorrhagic Fever, EbolaHumansInflammation MediatorsLongitudinal StudiesLymphocyte ActivationMalePatient DischargeProgrammed Cell Death 1 ReceptorSurvivorsT-LymphocytesViral LoadCTLA-4 AntigenCTLA4 protein, humanInflammation MediatorsPDCD1 protein, humanProgrammed Cell Death 1 Receptor
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