ArticleScientific reports2016
Sequence-based Association Analysis Reveals an MGST1 eQTL with Pleiotropic Effects on Bovine Milk Composition.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 4 of them syntheses that pooled it.
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Who cites it
75 citing papers in PubMed, 4 syntheses or guidelines pooled it, 208 citations in OpenAlex.
- Meta-analysis for milk fat and protein percentage using imputed sequence variant genotypes in 94,321 cattle from eight cattle breeds.Genetics, selection, evolution : GSE · 2020Pooled it
- Effect direction meta-analysis of GWAS identifies extreme, prevalent and shared pleiotropy in a large mammal.Communications biology · 2020Pooled it
- GWAS and eQTL analysis identifies a SNP associated with both residual feed intake and GFRA2 expression in beef cattle.Scientific reports · 2018Pooled it
- Meta-analysis of sequence-based association studies across three cattle breeds reveals 25 QTL for fat and protein percentages in milk at nucleotide resolution.BMC genomics · 2017Pooled it
- Resolving Cattle GWAS Loci: Current Progress, Persistent Challenges and Future Directions.Current issues in molecular biology · 2026Review
- Effects of the Temperature-Humidity Index on Milk Production Traits and Gene-Environment Interactions in Chinese Holstein Cows.Animals : an open access journal from MDPI · 2026Article
- Learning inherent genetic patterns and trait associations with deep generative models for discrete genotype simulation.GigaScience · 2026Article
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- Comparison of GBLUP and WGBLUP in genomic selection for beef cattle under different LD patterns and mixed multi-population scenarios: a simulation study.BMC genomics · 2025Article
- Structural and epistatic regulatory variants cause hallmark white spotting in cattle.Science advances · 2025Article
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- Sequence-based GWAS reveals genes and variants associated with predicted methane emissions in French dairy cows.Genetics, selection, evolution : GSE · 2025Article
- An integrative approach to prioritize candidate causal genes for complex traits in cattle.PLoS genetics · 2025Article
- Comparison of genomic prediction accuracies in dairy cattle lactation traits using five classes of functional variants versus generic SNP.Genetics, selection, evolution : GSE · 2025Article
- Mammary gland multi-omics data reveals new genetic insights into milk production traits in dairy cattle.PLoS genetics · 2025Article
- Sequence-based GWAS in 180,000 German Holstein cattle reveals new candidate variants for milk production traits.Genetics, selection, evolution : GSE · 2025Article
- Using expression data to fine map QTL associated with fertility in dairy cattle.Genetics, selection, evolution : GSE · 2024Article
- Cis-eQTLs in seven duck tissues identify novel candidate genes for growth and carcass traits.BMC genomics · 2024Article
- A common regulatory haplotype doubles lactoferrin concentration in milk.Genetics, selection, evolution : GSE · 2024Article
- Pangenome-genotyped structural variation improves molecular phenotype mapping in cattle.Genome research · 2024Article
15 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammary gland is a prolific lipogenic organ, synthesising copious amounts of triglycerides for secretion into milk. The fat content of milk varies widely both between and within species, and recent independent genome-wide association studies have highlighted a milk fat percentage quantitative trait locus (QTL) of large effect on bovine chromosome 5. Although both EPS8 and MGST1 have been proposed to underlie these signals, the causative status of these genes has not been functionally confirmed. To investigate this QTL in detail, we report genome sequence-based imputation and association mapping in a population of 64,244 taurine cattle. This analysis reveals a cluster of 17 non-coding variants spanning MGST1 that are highly associated with milk fat percentage, and a range of other milk composition traits. Further, we exploit a high-depth mammary RNA sequence dataset to conduct expression QTL (eQTL) mapping in 375 lactating cows, revealing a strong MGST1 eQTL underpinning these effects. These data demonstrate the utility of DNA and RNA sequence-based association mapping, and implicate MGST1, a gene with no obvious mechanistic relationship to milk composition regulation, as causally involved in these processes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.