ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2016
Left ventricular metabolism, function, and sympathetic innervation in men and women with type 1 diabetes.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 16 citations in OpenAlex.
- Psychometric Properties of Ecological Momentary Assessment of Psychosocial Functioning in Adults With Complications Related to Type 1 Diabetes.Canadian journal of diabetes · 2026Article
- Myocardial perfusion and oxidative metabolism in healthy subjects: sex-specific insights from vasodilatory stressEJNMMI research · 2025Article
- Glycaemic control, low levels of high-density lipoprotein, and high cardiovascular risk are associated with cardiovascular autonomic neuropathy.Diabetology & metabolic syndrome · 2025Article
- Evaluation of Non-infarct-Related Arteries Using C-11 Acetate PET in STEMI With Multivessel Disease.Journal of cardiovascular imaging · 2022Article
- Use of 55 PET radiotracers under approval of a Radioactive Drug Research Committee (RDRC).EJNMMI radiopharmacy and chemistry · 2020Article
- Recent advances in exercise pressor reflex function in health and disease.Autonomic neuroscience : basic & clinical · 2020Review
- Article
- Acute Effects of Insulin on Cardiac Function in Patients with Diabetes Mellitus: Clinical Applicability and Feasibility.International journal of endocrinology · 2020Article
- Review of Cardiovascular Imaging in the Journal of Nuclear Cardiology in 2016. Part 1 of 2: Positron Emission Tomography, Computed Tomography and Magnetic Resonance.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Review
- 'SeXX' matters: In the myocardium of patients with type 1 diabetes.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
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11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIn type I diabetes (T1DM), alterations in LV function may occur due to changes in innervation, metabolism, and efficiency.
objectivesWe evaluated the association between sympathetic nerve function, oxidative metabolism, resting blood flow, LV efficiency and function in healthy diabetics, and assessed gender differences.
methodsCross-sectional study of 45 subjects with T1DM, 60% females, age 34 ± 13 years, and 10 age-matched controls. Positron emission tomography (PET) imaging with [(11)C]acetate and [(11)C]meta-hydroxyephedrine was performed, in addition to cardiac magnetic resonance imaging.
resultsThere were no significant differences in LV function, innervation, or oxidative metabolism between T1DM and controls. Cardiac oxidative metabolism was positively associated with higher levels of sympathetic activation, particularly in women. Diabetic women had significantly lower efficiency compared with diabetic men. Resting flow was significantly higher in diabetic women compared with diabetic men, and tended to be higher in female controls as well.
conclusionsMeasures of myocardial function, metabolism, blood flow, and sympathetic activation were preserved in young, otherwise healthy, T1DM patients. However, T1DM women presented with greater myocardial oxidative metabolism requirements than men. Ongoing studies are evaluating changes over time.
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