Evidence map›Paper›PMID 27146517›Full record

ArticleScientific reports2016

Learning Bayesian Networks from Correlated Data.

Harold Bae, Stefano Monti, Monty Montano, Martin H Steinberg, Thomas T Perls, Paola Sebastiani

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Harold BaeOregon State University, College of Public Health and Human Sciences, Corvallis, 97331, USA.
Stefano MontiBoston University, Department of Medicine, Boston, 02118, USA.
Monty MontanoHarvard Medical School, Department of Medicine, Boston, 02115, USA.
Martin H SteinbergBoston University, Department of Medicine, Boston, 02118, USA.
Thomas T PerlsBoston University, Department of Medicine, Boston, 02118, USA.
Paola SebastianiBoston University, Department of Biostatistics, Boston, 02118, USA.
Boston University · USHarvard University · USOregon State University · US

Funding

Systems BiologyU19AG023122 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI JODI A LAPIDUS · 2004 to 2026
$102.6M
The Long Life Family StudyU01AG023755 · NIA · BOSTON MEDICAL CENTER · PI PERLS, THOMAS T · 2004 to 2018
$13.2M
Plasma beta-amyloid in long lived families: genetics and risk of ADU01AG023749 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI COSENTINO, STEPHANIE ANN, LEE, JOSEPH HYUNGWOO · 2004 to 2018
$13.0M
Interdisciplinary Training for BiostatisticiansT32GM074905 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WHITE, LAURA FORSBERG · 2005 to 2019
$3.0M
Effect of non genetic factors on genetic signatures of complex traitsR21HL114237 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SEBASTIANI, PAOLA · 2012 to 2014
$480k
NHLBI NIH HHS R21 HL114237NIA NIH HHS U01 AG023749NIA NIH HHS U01 AG023755NIA NIH HHS U19 AG023122NIGMS NIH HHS T32 GM074905
6 · The paper itself

Abstract

Bayesian networks are probabilistic models that represent complex distributions in a modular way and have become very popular in many fields. There are many methods to build Bayesian networks from a random sample of independent and identically distributed observations. However, many observational studies are designed using some form of clustered sampling that introduces correlations between observations within the same cluster and ignoring this correlation typically inflates the rate of false positive associations. We describe a novel parameterization of Bayesian networks that uses random effects to model the correlation within sample units and can be used for structure and parameter learning from correlated data without inflating the Type I error rate. We compare different learning metrics using simulations and illustrate the method in two real examples: an analysis of genetic and non-genetic factors associated with human longevity from a family-based study, and an example of risk factors for complications of sickle cell anemia from a longitudinal study with repeated measures.

Indexed as

Bayes TheoremLife ExpectancyAnemia, Sickle CellHumans

Identifiers

PMID27146517
PMCPMC4857179
OpenAlexW2346754386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.