ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2016
Impact of obesity and exercise on chemotherapy-related fatigue.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- The impact of weight loss on physical function and symptoms in overweight or obese breast cancer survivors: results from POWER-remote.Journal of cancer survivorship : research and practice · 2022Trial
- Article
- Impact of Diabetes on the Symptoms of Breast Cancer Survivors.Oncology nursing forum · 2019Article
- Obese Breast Cancer Patients and Survivors: Management Considerations.Oncology (Williston Park, N.Y.) · 2018Article
- Thyroid function in the etiology of fatigue in breast cancer.Oncotarget · 2018Article
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Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionBreast cancer patients undergoing adjuvant chemotherapy often develop fatigue from their treatment that may persist for months. While the positive effects of physical activity in cancer patients are increasingly recognized, the impact of obesity on chemotherapy-induced fatigue has not been well studied.
methodsFemale age 35-75 years with stage I-III breast cancer receiving adjuvant chemotherapy were enrolled in an IRB-approved study. Patient fatigue was self-reported using a 14-question fatigue symptom inventory. Patients were queried about fatigue and their level of exercise before, during, and after completion of chemotherapy. BMI was measured prior to their first cycle of chemotherapy.
resultsOf the 47 evaluable patients, 37 reported performing exercise on a regular basis. Following chemotherapy, 53 % of the exercise group and 80 % of the non-exercise group displayed a worsening of their FS. In patients with a BMI < 25, the fatigue score (FS) after chemotherapy was 27.6 in the exercise group versus 40.5 in the non-exercise group. In patients with a BMI > 25, the FS after chemotherapy was 25.96 in the exercise group versus 32.6 in the non-exercise group.
conclusionOur study indicates a trend towards fatigue reduction with exercise even in patients who are overweight. Thus, an elevated BMI at diagnosis does not preclude a breast cancer patient from experiencing the same positive effects from exercise on chemotherapy-related fatigue as patients with normal BMIs. This indicates an important role of physicians in the primary care setting to encourage patients to initiate physical activity when offering cancer-screening services.
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