ArticleJournal of the American Heart Association2016
Adipose Tissue Depots and Their Cross-Sectional Associations With Circulating Biomarkers of Metabolic Regulation.
Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 42 citations in OpenAlex.
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- Changes in uric acid metabolism and associated plasma proteomics during sex hormone therapy.Journal of clinical & translational endocrinology · 2026Article
- Retinal Microvascular Calibres and Body Fat Indices in Young Adults.International journal of environmental research and public health · 2026Article
- Advances in the Role of Adipose Tissue in Promoting Injury Repair and Resist Infection.Immunity, inflammation and disease · 2026Review
- Article
- Neck Circumference and the Heart: Unveiling a New Anthropometric Marker for LVH Risk in Type 2 Diabetes-The TESEO Study.Diabetes/metabolism research and reviews · 2025Article
- Associations of Markers of Inflammatory Status and Adiposity with Bone Phenotype at Age 60-64 Years: Findings from the MRC National Survey of Health and Development.Calcified tissue international · 2025Article
- Body composition as a potential imaging biomarker for predicting the progression risk of chronic kidney disease.Insights into imaging · 2024Article
- Skeletal muscle and visceral adipose radiodensities are pre-surgical, non-invasive markers of aggressive kidney cancer.Journal of cachexia, sarcopenia and muscle · 2024Article
- Ectopic and visceral fat deposition in aging, obesity, and idiopathic pulmonary fibrosis: an interconnected role.Lipids in health and disease · 2023Review
- Fat, adipokines, bone structure and bone regulatory factors associations in obesity.European journal of endocrinology · 2022Observational
- Cardiovascular Biomarkers of Obesity and Overlap With Cardiometabolic Dysfunction.Journal of the American Heart Association · 2021Article
- Serum fatty acid-binding protein 4 levels and responses of pancreatic islet β-cells and α-cells in patients with type 2 diabetes.Diabetology & metabolic syndrome · 2021Article
- The Dynamic Platelet Transcriptome in Obesity and Weight Loss.Arteriosclerosis, thrombosis, and vascular biology · 2021Article
- Metabolomics profiling of visceral and abdominal subcutaneous adipose tissue in colorectal cancer patients: results from the ColoCare study.Cancer causes & control : CCC · 2020Article
- Early weaning leads to specific glucocorticoid signalling in fat depots of adult rats.Endocrine · 2020Article
- Changes in Proteomic Profiles are Related to Changes in BMI and Fat Distribution During 10 Years of Aging.Obesity (Silver Spring, Md.) · 2020Article
- Nanotechnology advances towards development of targeted-treatment for obesity.Journal of nanobiotechnology · 2019Review
- Association of Alcohol Consumption With Fat Deposition in a Community-Based Sample of Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA).Journal of epidemiology · 2019Article
- Fatty Acid-Binding Protein 4 in Cardiovascular and Metabolic Diseases.Journal of atherosclerosis and thrombosis · 2019Review
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundVisceral adipose tissue (VAT) and fatty liver differ in their associations with cardiovascular risk compared with subcutaneous adipose tissue (SAT). Several biomarkers have been linked to metabolic derangements and may contribute to the pathogenicity of fat depots. We examined the association between fat depots on multidetector computed tomography and metabolic regulatory biomarkers. METHODS AND
resultsParticipants from the Framingham Heart Study (n=1583, 47% women) underwent assessment of SAT, VAT, and liver attenuation. We measured circulating biomarkers secreted by adipose tissue or liver (adiponectin, leptin, leptin receptor, fatty acid binding protein 4, fetuin-A, and retinol binding protein 4). Using multivariable linear regression models, we examined relations of fat depots with biomarkers. Higher levels of fat depots were positively associated with leptin and fatty acid binding protein 4 but negatively associated with adiponectin (all P<0.001). Associations with leptin receptor, fetuin-A, and retinol binding protein 4 varied according to fat depot type or sex. When comparing the associations of SAT and VAT with biomarkers, VAT was the stronger correlate of adiponectin (β=-0.28 [women]; β=-0.30 [men]; both P<0.001), whereas SAT was the stronger correlate of leptin (β=0.62 [women]; β=0.49 [men]; both P<0.001; P<0.001 for comparing VAT versus SAT). Although fetuin-A and retinol binding protein 4 are secreted by the liver in addition to adipose tissue, associations of liver attenuation with these biomarkers was not stronger than that of SAT or VAT.
conclusionsSAT, VAT, and liver attenuation are associated with metabolic regulatory biomarkers with differences in the associations by fat depot type and sex. These findings support the possibility of biological differences between fat depots.
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