Evidence map›Paper›PMID 27146421›Full record

Trial reportMolecular imaging and biology2016

[

Richard Laforest, Suzanne E Lapi, Reiko Oyama, Ron Bose, Adel Tabchy, Bernadette V Marquez-Nostra, Jennifer Burkemper, Brian D Wright, Jennifer Frye, Sarah Frye and 2 more

Abstract readClinical Trial
In one paragraph

Trial report in Molecular imaging and biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Phase I Study ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Trial
  4. Pharmacokinetics, Biodistribution, and Radiation Dosimetry forJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018
    Trial
  5. Trial
  6. Development of novel GPC2-directed radiotheranostics and CAR T cell therapy for neuroblastoma.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  7. Article
  8. Evaluation ofACS omega · 2026
    Article
  9. Article
  10. Advances in GPCR-Targeted PET Radiotracer Patents (2020-2025).Pharmaceuticals (Basel, Switzerland) · 2026
    Review
  11. A phase I study to evaluate the dosimetry and safety of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  12. Review
  13. Review
  14. PET Imaging of CD38 and IND enabling studies of [Molecular imaging and biology · 2026
    Article
  15. A Bioimaging Study ofMolecular imaging and biology · 2026
    Article
  16. Article
  17. Quantitative [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  18. Review
  19. Pharmaceutics · 2025
    Article
  20. Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Richard LaforestDivision of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA. laforestr@wustl.edu.
Suzanne E LapiDivision of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Reiko OyamaDivision of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Ron BoseThe Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.
Adel TabchyDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Bernadette V Marquez-NostraDivision of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Jennifer BurkemperDivision of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Brian D WrightDivision of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Jennifer FryeDivision of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Sarah FryeDivision of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Barry A SiegelThe Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.
Farrokh DehdashtiThe Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.

Funding

A FEASIBILITY PET STUDY OF HER2 RECEPTORS IN BREAST CANCER USING 89ZR-TRASTUZUMABR21CA182945 · NCI · WASHINGTON UNIVERSITY · PI DEHDASHTI, FARROKH · 2014 to 2015
$631k
NCI NIH HHS R21 CA182945
6 · The paper itself

Abstract

purposeThe purpose of the present study is to evaluate safety, human radiation dosimetry, and optimal imaging time of [ PROCEDURES: Twelve women with HER2-positive breast cancer underwent [

resultsHigh-quality images and the greatest tumor-to-nontumor contrast were achieved with images performed 5 ± 1 day post-injection. Increased [

conclusion[

Indexed as

AdultAgedBreast NeoplasmsErb-b2 Receptor Tyrosine KinasesFemaleHumansMiddle AgedPositron Emission Tomography Computed TomographyRadioisotopesRadiometryTime FactorsTissue DistributionTrastuzumabZirconiumErb-b2 Receptor Tyrosine KinasesRadioisotopesTrastuzumabZirconiumDosimetryHER2PET imagingTrastuzumabZirconium-89

Identifiers

PMID27146421
PMCPMC5096950

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.