ArticleBone & joint research2016
The pathobiology and pathology of aseptic implant failure.
Article in Bone & joint research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 126 citations in OpenAlex.
- Circulating monocytes from aseptic loosening patients exhibit enhanced tropism toward periprosthetic tissues in NOD-SCID mouse model.Scientific reports · 2026Article
- Toward next-generation hip implants: From failure mechanisms to translational design.Journal of orthopaedic translation · 2026Review
- Factors associated with aseptic loosening after primary total hip arthroplasty: A systematic review and meta-analysis.World journal of orthopedics · 2026Article
- Thermal Effects of Burr and Saw Cutting Tools in Total Knee Arthroplasty.Advances in orthopedics · 2026Article
- CT-Based Radiostereometric Analysis: A Promising Alternative to Conventional Radiostereometric Analysis in Determining Polyethylene Wear in Total Hip Arthroplasty.Advances in orthopedics · 2026Article
- Kinetics and Fluid-Specific Behavior of Metal Ions After Hip Replacement.Bioengineering (Basel, Switzerland) · 2025Article
- Repeated exposure to CoCr28Mo6 particles leads to activation of NLRP3 inflammasome signaling in human osteoblasts.Cell biology and toxicology · 2025Article
- Glycoprotein non-metastatic melanoma protein B is a potential biomarker for arthroplasty aseptic loosening.Scientific reports · 2025Article
- Liposomes as Imaging Agents of Inflammation and Oxidative Stress in Bone Implants.Current issues in molecular biology · 2025Review
- Spinal implant wear particles: Generation, characterization, biological impacts, and future considerations.iScience · 2025Review
- Post-Implantation Syndrome Incidence After Secondary Endovascular Aortic Interventions.EJVES vascular forum · 2025Article
- Identification of immune-related diagnostic genes and immune cell infiltration in aseptic loosening of prostheses after total hip arthroplasty by integrated bioinformatics analysis and experimental confirmation.Frontiers in genetics · 2025Article
- A comparison of cemented femoral fixation via anterior versus posterior approach total hip arthroplasty: an analysis of 60,739 total hip arthroplasties.Hip international : the journal of clinical and experimental research on hip pathology and therapy · 2024Article
- The activity of monocyte-derived macrophages after stimulation with platelet-rich and platelet-poor concentrates. Study on an ovine model of insertion of a tibial implant coated with silicon-doped diamond-like carbon.Journal of veterinary research · 2024Article
- Review
- How Can Imbalance in Oral Microbiota and Immune Response Lead to Dental Implant Problems?International journal of molecular sciences · 2023Review
- Bisphosphonates' use and risk of aseptic loosening following total hip arthroplasty: a systematic review.EFORT open reviews · 2023Article
- Mass spectrometry-based proteomic profiling of sonicate fluid differentiates Staphylococcus aureus periprosthetic joint infection from non-infectious failure: A pilot study.Proteomics. Clinical applications · 2023Article
- Inflammatory, Oxidative Stress and Small Cellular Particle Response in HUVEC Induced by Debris from Endoprosthesis Processing.Materials (Basel, Switzerland) · 2023Article
- CoNiCrMo Particles, but Not TiAlV Particles, Activate the NLRP3 Inflammasome in Periprosthetic Cells.International journal of molecular sciences · 2023Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathological assessment of periprosthetic tissues is important, not only for diagnosis, but also for understanding the pathobiology of implant failure. The host response to wear particle deposition in periprosthetic tissues is characterised by cell and tissue injury, and a reparative and inflammatory response in which there is an innate and adaptive immune response to the material components of implant wear. Physical and chemical characteristics of implant wear influence the nature of the response in periprosthetic tissues and account for the development of particular complications that lead to implant failure, such as osteolysis which leads to aseptic loosening, and soft-tissue necrosis/inflammation, which can result in pseudotumour formation. The innate response involves phagocytosis of implant-derived wear particles by macrophages; this is determined by pattern recognition receptors and results in expression of cytokines, chemokines and growth factors promoting inflammation and osteoclastogenesis; phagocytosed particles can also be cytotoxic and cause cell and tissue necrosis. The adaptive immune response to wear debris is characterised by the presence of lymphoid cells and most likely occurs as a result of a cell-mediated hypersensitivity reaction to cell and tissue components altered by interaction with the material components of particulate wear, particularly metal ions released from cobalt-chrome wear particles.Cite this article: Professor N. A. Athanasou. The pathobiology and pathology of aseptic implant failure. Bone Joint Res 2016;5:162-168. DOI: 10.1302/2046-3758.55.BJR-2016-0086.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.