Evidence map›Paper›PMID 27146311›Full record

ReviewAnnual review of cell and developmental biology2016

The Role of Adipocytes in Tissue Regeneration and Stem Cell Niches.

Brett Shook, Guillermo Rivera Gonzalez, Sarah Ebmeier, Gabriella Grisotti, Rachel Zwick, Valerie Horsley

Open access · bronzeAbstract readReview
In one paragraph

Review in Annual review of cell and developmental biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. One Size Does Not Fit All: Diversifying Immune Function in the Skin.Journal of immunology (Baltimore, Md. : 1950) · 2022
    Review
  11. Article
  12. Article
  13. Hematopoietic Stem Cells: Nature and Niche Nurture.Bioengineering (Basel, Switzerland) · 2021
    Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Lung-resident mesenchymal stromal cells are tissue-specific regulators of lung homeostasis.American journal of physiology. Lung cellular and molecular physiology · 2020
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Brett ShookDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520; email: valerie.horsley@yale.edu.
Guillermo Rivera GonzalezDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520; email: valerie.horsley@yale.edu.
Sarah EbmeierDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520; email: valerie.horsley@yale.edu.
Gabriella GrisottiDepartment of Surgery, Yale University, New Haven, Connecticut 06520.
Rachel ZwickDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520; email: valerie.horsley@yale.edu.
Valerie HorsleyDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520; email: valerie.horsley@yale.edu.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Skill Development for Diverse Scientific Careers: A New Course Predoctoral Program in Cellular and Molecular BiologyT32GM007223 · NIGMS · YALE UNIVERSITY · PI BASERGA, SUSAN J · 1985 to 2019
$31.0M
Extrinsic Regulation of Epidermal HomeostatasisR01AR060295 · NIAMS · YALE UNIVERSITY · PI HORSLEY, VALERIE · 2011 to 2016
$2.2M
Mechanisms that Regulate Skin Wound HealingR01AR069550 · NIAMS · YALE UNIVERSITY · PI HORSLEY, VALERIE · 2016 to 2020
$1.8M
Extrinsic Regulation that Regulate Skin HomeostasisR56AR060295 · NIAMS · YALE UNIVERSITY · PI HORSLEY, VALERIE · 2018 to 2018
$481k
NCATS NIH HHS UL1 TR001863NIAMS NIH HHS R01 AR060295NIAMS NIH HHS R01 AR069550NIAMS NIH HHS R56 AR060295NIGMS NIH HHS T32 GM007223
6 · The paper itself

Abstract

Classically, white adipose tissue (WAT) was considered an inert component of connective tissue but is now appreciated as a major regulator of metabolic physiology and endocrine homeostasis. Recent work defining how WAT develops and expands in vivo emphasizes the importance of specific locations of WAT or depots in metabolic regulation. Interestingly, mature white adipocytes are integrated into several tissues. A new perspective regarding the in vivo regulation and function of WAT in these tissues has highlighted an essential role of adipocytes in tissue homeostasis and regeneration. Finally, there has been significant progress in understanding how mature adipocytes regulate the pathology of several diseases. In this review, we discuss these novel roles of WAT in the homeostasis and regeneration of epithelial, muscle, and immune tissues and how they contribute to the pathology of several disorders.

Indexed as

OrganogenesisStem Cell NicheAdipocytesAnimalsDiseaseHumansModels, BiologicalRegenerationadipocyteadipose tissueregenerationskin

Identifiers

PMID27146311
PMCPMC5157158
OpenAlexW2345880211

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.