ArticleNeuron2016
Mnemonic Functions for Nonlinear Dendritic Integration in Hippocampal Pyramidal Circuits.
Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Maintaining and regaining episodic memory in Alzheimer disease: a circuit-based perspective.Nature reviews. Neurology · 2026Review
- Acupuncture as a modulator of microglial polarization and pyroptosis in depression: evidence from a chronic unpredictable mild stress rat model.Metabolic brain disease · 2026Article
- Understanding the Antidepressant Mechanisms of Acupuncture: Targeting Hippocampal Neuroinflammation, Oxidative Stress, Neuroplasticity, and Apoptosis in CUMS Rats.Molecular neurobiology · 2025Article
- Dendrites endow artificial neural networks with accurate, robust and parameter-efficient learning.Nature communications · 2025Article
- Dendrites endow artificial neural networks with accurate, robust and parameter-efficient learning.ArXiv · 2024Article
- Learning to use landmarks for navigation amplifies their representation in retrosplenial cortex.bioRxiv : the preprint server for biology · 2024Article
- Functional architecture of intracellular oscillations in hippocampal dendrites.Nature communications · 2024Article
- Functional architecture of intracellular oscillations in hippocampal dendrites.bioRxiv : the preprint server for biology · 2024Article
- Distinguishing examples while building concepts in hippocampal and artificial networks.Nature communications · 2024Article
- Article
- A local circuit-basis for spatial navigation and memory processes in hippocampal area CA1.Current opinion in neurobiology · 2023Review
- Brain reserve contributes to distinguishing preclinical Alzheimer's stages 1 and 2.Alzheimer's research & therapy · 2023Article
- Impaired dendritic spike generation in the Fragile X prefrontal cortex is due to loss of dendritic sodium channels.The Journal of physiology · 2023Article
- Introducing the Dendrify framework for incorporating dendrites to spiking neural networks.Nature communications · 2023Article
- The dendritic engram.Frontiers in behavioral neuroscience · 2023Article
- Hemisphere-specific spatial representation by hippocampal granule cells.Nature communications · 2022Article
- Computational models reveal how chloride dynamics determine the optimal distribution of inhibitory synapses to minimise dendritic excitability.PLoS computational biology · 2022Article
- Article
- Basal Forebrain-Dorsal Hippocampus Cholinergic Circuit Regulates Olfactory Associative Learning.International journal of molecular sciences · 2022Article
- A direct lateral entorhinal cortex to hippocampal CA2 circuit conveys social information required for social memory.Neuron · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
We present a model for neural circuit mechanisms underlying hippocampal memory. Central to this model are nonlinear interactions between anatomically and functionally segregated inputs onto dendrites of pyramidal cells in hippocampal areas CA3 and CA1. We study the consequences of such interactions using model neurons in which somatic burst-firing and synaptic plasticity are controlled by conjunctive processing of these separately integrated input pathways. We find that nonlinear dendritic input processing enhances the model's capacity to store and retrieve large numbers of similar memories. During memory encoding, CA3 stores heavily decorrelated engrams to prevent interference between similar memories, while CA1 pairs these engrams with information-rich memory representations that will later provide meaningful output signals during memory recall. While maintaining mathematical tractability, this model brings theoretical study of memory operations closer to the hippocampal circuit's anatomical and physiological properties, thus providing a framework for future experimental and theoretical study of hippocampal function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.