ArticleMolecular microbiology2016
Function, expression, specificity, diversity and incompatibility of actinobacteriophage parABS systems.
Article in Molecular microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 39 citations in OpenAlex.
- Versatile NTP recognition and domain fusions expand the functional repertoire of the ParB-CTPase fold beyond chromosome segregation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Evolutionary selection of trimethoprim-resistantScience advances · 2025Article
- Genome Sequences of Cluster A Mycobacteriophages Dorothea and LappelDuVide, Isolated onmicroPublication biology · 2025Article
- Characteristics of phage-plasmids and their impact on microbial communities.Essays in biochemistry · 2024Review
- Reclassification of the first Bacillus tropicus phage calls for reclassification of other Bacillus temperate phages previously designated as plasmids.BMC genomics · 2024Article
- Introducing Casbah, Kronus, and MmasiCarm, Members of the Mycobacteriophage Subcluster B3.PHAGE (New Rochelle, N.Y.) · 2024Article
- Genome sequences ofMicrobiology resource announcements · 2024Article
- Diversity ofMicrobiology spectrum · 2024Article
- Genome sequence of cluster A15Microbiology resource announcements · 2023Article
- Human-Gut Phages Harbor Sporulation Genes.mBio · 2023Article
- Comparative Genomics of Six LyticPHAGE (New Rochelle, N.Y.) · 2022Article
- A Review on Mycobacteriophages: From Classification to Applications.Pathogens (Basel, Switzerland) · 2022Review
- Phylogenetic Distribution of WhiB- and Lsr2-Type Regulators in Actinobacteriophage Genomes.Microbiology spectrum · 2021Article
- Phylogenomic Characterization of a NovelmSystems · 2021Article
- The Prophage and Plasmid Mobilome as a Likely Driver of Mycobacterium abscessus Diversity.mBio · 2021Article
- Bacteria have numerous distinctive groups of phage-plasmids with conserved phage and variable plasmid gene repertoires.Nucleic acids research · 2021Article
- Mycobacteriophages as Potential Therapeutic Agents against Drug-Resistant Tuberculosis.International journal of molecular sciences · 2021Review
- Actinobacteriophages: Genomics, Dynamics, and Applications.Annual review of virology · 2020Review
- Characterization and spontaneous induction of urinary tractThe Journal of general virology · 2020Article
- Protein-Mediated and RNA-Based Origins of Replication of Extrachromosomal Mycobacterial Prophages.mBio · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
More than 180 individual phages infecting hosts in the phylum Actinobacteria have been sequenced and grouped into Cluster A because of their similar overall nucleotide sequences and genome architectures. These Cluster A phages are either temperate or derivatives of temperate parents, and most have an integration cassette near the centre of the genome containing an integrase gene and attP. However, about 20% of the phages lack an integration cassette, which is replaced by a 1.4 kbp segment with predicted partitioning functions, including plasmid-like parA and parB genes. Phage RedRock forms stable lysogens in Mycobacterium smegmatis in which the prophage replicates at 2.4 copies/chromosome and the partitioning system confers prophage maintenance. The parAB genes are expressed upon RedRock infection of M. smegmatis, but are downregulated once lysogeny is established by binding of RedRock ParB to parS-L, one of two centromere-like sites flanking the parAB genes. The RedRock parS-L and parS-R sites are composed of eight directly repeated copies of an 8 bp motif that is recognized by ParB. The actinobacteriophage parABS cassettes span considerable sequence diversity and specificity, providing a suite of tools for use in mycobacterial genetics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.