Evidence map›Paper›PMID 27146043›Full record

ArticleJournal of gastrointestinal cancer2016

Fibrosis and Mast Cells in Colorectal Lesions: Significance in Adenoma-Colorectal Cancer Sequence and Association with Diet.

Izabela Sinara Silva Alves, Pedro Henrique Piras Coser, Giovanni José Zucoloto Loureiro, Luciano Pinto Nogueira da Gama, Flavya da Silva Souza Ribeiro, Willian Grassi Bautz, Karla Loureiro Almeida Coburn, Marcos da Silva Pacheco, Letícia Nogueira da Gama de Souza

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Article in Journal of gastrointestinal cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Izabela Sinara Silva AlvesDepartment of Morphology, Federal University of Espírito Santo, Health of Sciences Center, Marechal Campos av., 1468, Maruípe, 29.040-090, Vitória, ES, Brazil.
Pedro Henrique Piras CoserDepartment of Morphology, Federal University of Espírito Santo, Health of Sciences Center, Marechal Campos av., 1468, Maruípe, 29.040-090, Vitória, ES, Brazil.
Giovanni José Zucoloto LoureiroDepartment of Coloproctology, Vitória ApartHospital, BR-101 North, km 2.38, Boa Vista II, Serra, ES, Brazil.
Luciano Pinto Nogueira da GamaDepartment of Coloproctology, Vitória ApartHospital, BR-101 North, km 2.38, Boa Vista II, Serra, ES, Brazil.
Flavya da Silva Souza RibeiroPAT Laboratory Medicine, Constante Sodré street, no. 346, Santa Lúcia, Vitória, ES, CEP: 29.055-420, Brazil.
Willian Grassi BautzDepartment of Morphology, Federal University of Espírito Santo, Health of Sciences Center, Marechal Campos av., 1468, Maruípe, 29.040-090, Vitória, ES, Brazil.
Karla Loureiro Almeida CoburnDepartment of Morphology, Federal University of Espírito Santo, Health of Sciences Center, Postgraduate Program in Dental Clinic (PPGCO), Marechal Campos av., 1468, Maruípe, 29.040-090, Vitória, ES, Brazil.
Marcos da Silva PachecoDepartment of Morphology, Federal University of Espírito Santo, Health of Sciences Center, Marechal Campos av., 1468, Maruípe, 29.040-090, Vitória, ES, Brazil.
Letícia Nogueira da Gama de SouzaDepartment of Morphology, Federal University of Espírito Santo, Health of Sciences Center, Postgraduate Program in Dental Clinic (PPGCO), Marechal Campos av., 1468, Maruípe, 29.040-090, Vitória, ES, Brazil. leticia.souza@ufes.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAdenoma is the most common benign neoplasm with potential to progress into colorectal cancer (CRC), a disease responsible for high rates of mortality. However, it is not possible yet to establish which lesions will evolve into CRC. We aimed to investigate the intrinsic factors, diet profile, and microenvironment as factors involved in adenoma-CRC progression.

methodsWe evaluated nutritional profile and microscopic features. Adenomas and CRC lesions were stained with Mallory's trichrome to reveal fibrosis and Alcian blue to identify mast cells.

resultsA total of 143 patients was selected, 66 % diagnosed with normal mucosa, 28.4 % with benign lesion, and 5.6 % with CRC. A higher frequency of lesions was associated with patients older than 50 years (26.57 %) and women (18.18 %), but men were more likely to develop CRC. Regarding microscopic aspects, epithelium-connective tissue interface with disorganization feature was significantly higher in CRC when compared to adenoma (P = 0.0007). A greater fibrosis around vessels was also observed in CRC (P = 0.01). The statistical analysis indicated a significant correlation between mast cell population and patients older than 50 years (P < 0.01), male (P < 0.01), with right colon lesion (P < 0.05) and CRC. Low consumption of leafy greens (P < 0.001) and carotenoids (P < 0.01) and elevated consumption of red meat (P < 0.001) were associated with a high density of mast cells.

conclusionsAn association between clinical, diet profile, and microscopic features in colorectal lesions was observed, with a progressive change in the microenvironment during adenoma-CRC sequence.

Indexed as

DietAdenomaColonoscopyColorectal NeoplasmsDisease ProgressionFemaleFibrosisHumansMaleMast CellsMiddle AgedAdenomaColorectal cancerDietFibrosisMast cells

Identifiers

PMID27146043

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.