ArticleScientific reports2016
Rupture Forces among Human Blood Platelets at different Degrees of Activation.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- The effects of splenectomy, platelet-rich plasma (PRP) and concentrated growth factor (CGF) on liver regeneration following major hepatectomy in rats.Scientific reports · 2026Article
- Blood concentrates for controlling postoperative complications from third molar surgeries: a scoping review.Acta cirurgica brasileira · 2025Article
- Platelet-Rich Plasma-Embedded Porous Polycaprolactone Film with a Large Surface Area for Effective Hemostasis.Tissue engineering and regenerative medicine · 2024Article
- Bioinspired chitosan based functionalization of biomedical implant surfaces for enhanced hemocompatibility, antioxidation and anticoagulation potential: anRSC advances · 2024Article
- The use of scanning electron microscopy and fixation methods to evaluate the interaction of blood with the surfaces of medical devices.Scientific reports · 2024Article
- Force balance ratio is a robust predictor of arterial thrombus stability.Biophysical journal · 2024Article
- Biomechanical activation of blood platelets via adhesion to von Willebrand factor studied with mesoscopic simulations.Biomechanics and modeling in mechanobiology · 2023Article
- Synthesis of Biocompatible Superparamagnetic Iron Oxide Nanoparticles (SPION) under Different Microfluidic Regimes.ACS applied materials & interfaces · 2022Article
- When Will Fondaparinux Induce Thrombocytopenia?Bioconjugate chemistry · 2022Article
- Ex vivo anticoagulants affect human blood platelet biomechanics with implications for high-throughput functional mechanophenotyping.Communications biology · 2022Article
- Controlling Surface-Induced Platelet Activation by Agarose and Gelatin-Based Hydrogel Films.ACS omega · 2021Article
- Modeling Thrombus Shell: Linking Adhesion Receptor Properties and Macroscopic Dynamics.Biophysical journal · 2021Article
- Mitoquinone (MitoQ) Inhibits Platelet Activation Steps by Reducing ROS Levels.International journal of molecular sciences · 2020Article
- Blood Clot Phenotyping by Rheometry: Platelets and Fibrinogen Chemistry Affect Stress-Softening and -Stiffening at Large Oscillation Amplitude.Molecules (Basel, Switzerland) · 2020Article
- Statistical analysis of 3D localisation microscopy images for quantification of membrane protein distributions in a platelet clot model.PLoS computational biology · 2020Article
- A Comprehensive Review of Concentrated Growth Factors and Their Novel Applications in Facial Reconstructive and Regenerative Medicine.Aesthetic plastic surgery · 2020Review
- Quantifying single-platelet biomechanics: An outsider's guide to biophysical methods and recent advances.Research and practice in thrombosis and haemostasis · 2020Review
- PTFEP-AlNanoscale advances · 2019Article
- Cuboidal tethered cyclodextrin frameworks tailored for hemostasis and injured vessel targeting.Theranostics · 2019Article
- Platelet biomechanics, platelet bioenergetics, and applications to clinical practice and translational research.Platelets · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Little is known about mechanics underlying the interaction among platelets during activation and aggregation. Although the strength of a blood thrombus has likely major biological importance, no previous study has measured directly the adhesion forces of single platelet-platelet interaction at different activation states. Here, we filled this void first, by minimizing surface mediated platelet-activation and second, by generating a strong adhesion force between a single platelet and an AFM cantilever, preventing early platelet detachment. We applied our setup to measure rupture forces between two platelets using different platelet activation states, and blockade of platelet receptors. The rupture force was found to increase proportionally to the degree of platelet activation, but reduced with blockade of specific platelet receptors. Quantification of single platelet-platelet interaction provides major perspectives for testing and improving biocompatibility of new materials; quantifying the effect of drugs on platelet function; and assessing the mechanical characteristics of acquired/inherited platelet defects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.