ArticleBiology direct2016
Beyond Turing: mechanochemical pattern formation in biological tissues.
Article in Biology direct, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 38 citations in OpenAlex.
- Modeling mechanochemical coupling in optogenetically activated cell layers.Biophysical journal · 2026Article
- Stochastic morphological swings inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Cell shape anisotropy contributes to self-organized feather pattern fidelity in birds.PLoS biology · 2022Article
- Network representation and analysis of energy coupling mechanisms in cellular metabolism by a graph-theoretical approach.Theory in biosciences = Theorie in den Biowissenschaften · 2022Article
- Pattern formation features might explain homoplasy: fertile surfaces in higher fungi as an example.Theory in biosciences = Theorie in den Biowissenschaften · 2022Review
- Mechanical Regulation of Limb Bud Formation.Cells · 2022Review
- From embryos to embryoids: How external signals and self-organization drive embryonic development.Stem cell reports · 2021Review
- Chemically controlled pattern formation in self-oscillating elastic shells.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- On the problem of biological form.Theory in biosciences = Theorie in den Biowissenschaften · 2020Article
- Review
- Tissue rheology in embryonic organization.The EMBO journal · 2019Review
- Emergence of form in embryogenesis.Journal of the Royal Society, Interface · 2018Article
- Post-Turing tissue pattern formation: Advent of mechanochemistry.PLoS computational biology · 2018Article
- Role of the boundary in feather bud formation on one-dimensional bioengineered skin.APL bioengineering · 2018Article
- Combining Turing and 3D vertex models reproduces autonomous multicellular morphogenesis with undulation, tubulation, and branching.Scientific reports · 2018Article
- Inceptions of biomathematics from Lotka to Thom.Science progress · 2017Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDuring embryogenesis, chemical (morphogen) and mechanical patterns develop within tissues in a self-organized way. More than 60 years ago, Turing proposed his famous reaction-diffusion model for such processes, assuming chemical interactions as the main driving force in tissue patterning. However, experimental identification of corresponding molecular candidates is still incomplete. Recent results suggest that beside morphogens, also tissue mechanics play a significant role in these patterning processes.
resultsCombining continuous finite strain with discrete cellular tissue models, we present and numerically investigate mechanochemical processes, in which morphogen dynamics and tissue mechanics are coupled by feedback loops. We consider three different mechanical cues involved in such feedbacks: strain, stress, and compression. Based on experimental results, for each case, we present a feedback loop spontaneously creating robust mechanochemical patterns. In contrast to Turing-type models, simple mechanochemical interaction terms are sufficient to create de novo patterns.
conclusionsOur results emphasize mechanochemical processes as possible candidates controlling different steps of embryogenesis. To motivate further experimental research discovering related mechanisms in living tissues, we also present predictive in silicio experiments. REVIEWERS: Reviewer 1 - Marek Kimmel; Reviewer 2 - Konstantin Doubrovinski (nominated by Ned Wingreen); Reviewer 3 - Jun Allard (nominated by William Hlavacek).
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