Evidence map›Paper›PMID 27145763›Full record

ReviewJournal of neural transmission (Vienna, Austria : 1996)2016

Cross-generational influences on childhood anxiety disorders: pathways and mechanisms.

Eli R Lebowitz, James F Leckman, Wendy K Silverman, Ruth Feldman

Open access · greenAbstract readReview
In one paragraph

Review in Journal of neural transmission (Vienna, Austria : 1996), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Early-life neural correlates of behavioral inhibition and anxiety risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Eli R LebowitzYale Child Study Center, 230 S. Frontage Rd., New Haven, CT, 06515, USA. eli.lebowitz@yale.edu.
James F LeckmanYale Child Study Center, 230 S. Frontage Rd., New Haven, CT, 06515, USA.
Wendy K SilvermanYale Child Study Center, 230 S. Frontage Rd., New Haven, CT, 06515, USA.
Ruth FeldmanGonda Brain Research, Bar Ilan University, Ramat Gan, Israel.
Yale University · USBar-Ilan University · IL

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Explanatory Clinical Trial of a Novel Parent Intervention for Childhood AnxietyK23MH103555 · NIMH · YALE UNIVERSITY · PI LEBOWITZ, ELI · 2014 to 2017
$703k
NCATS NIH HHS UL1 TR001863NIMH NIH HHS K23 MH103555
6 · The paper itself

Abstract

Anxiety disorders are common across the lifespan, cause severe distress and impairment, and usually have their onset in childhood. Substantial clinical and epidemiological research has demonstrated the existence of links between anxiety and its disorders in children and parents. Research on the pathways and mechanisms underlying these links has pointed to both behavioral and biological systems. This review synthesizes and summarizes several major aspects of this research. Behavioral systems include vicarious learning, social referencing, and modeling of parental anxiety; overly protective or critical parenting styles; and aspects of parental responses to child anxiety including family accommodation of the child's symptoms. Biological systems include aspects of the prenatal environment affected by maternal anxiety, development and functioning of the oxytocinergic system, and genetic and epigenetic transmission. Implications for the prevention and treatment of child anxiety disorders are discussed, including the potential to enhance child anxiety treatment outcomes through biologically informed parent-based interventions.

Indexed as

Anxiety DisordersParent-Child RelationsChildEnvironmentFemaleHumansMaleOxytocinParentingParentsOxytocinAnxiety disordersChildGeneticsMother–child relationsOxytocin

Identifiers

PMID27145763
PMCPMC5007197
OpenAlexW2346337026

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.