ArticleJournal of general internal medicine2016
Incident Type 2 Diabetes Risk is Influenced by Obesity and Diabetes in Social Contacts: a Social Network Analysis.
Article in Journal of general internal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Spousal diabetes status as a risk factor for incident type 2 diabetes: a prospective cohort study and meta-analysis.Acta diabetologica · 2019Pooled it
- A scalable online tool for quantitative social network assessment reveals potentially modifiable social environmental risks.Nature communications · 2018Trial
- Predictive effect of the triglyceride glucose index on abnormal blood glucose metabolism events in populations with sarcopenia: a cross-sectional study.BMC endocrine disorders · 2025Article
- The incidence and influencing factors of type 2 diabetes mellitus in Chinese adults in 10 provinces: a prospective cohort study.BMC public health · 2025Article
- Vulnerability or Resiliency? A Two-Wave Panel Analysis of Social Network Factors Associated with Glycemic Levels among Mexican Immigrants in the Bronx, NYC, Before and During COVID-19.Journal of urban health : bulletin of the New York Academy of Medicine · 2024Article
- Comparison of insulin resistance-associated parameters in US adults: a cross-sectional study.Hormones (Athens, Greece) · 2023Article
- Predictive Effect of Triglyceride Glucose-Related Parameters, Obesity Indices, and Lipid Ratios for Diabetes in a Chinese Population: A Prospective Cohort Study.Frontiers in endocrinology · 2022Article
- Impacts of Triglyceride Glucose-Waist to Height Ratio on Diabetes Incidence: A Secondary Analysis of A Population-Based Longitudinal Data.Frontiers in endocrinology · 2022Article
- Social networks and type 2 diabetes: a narrative review.Diabetologia · 2021Review
- Triglyceride glucose index as a tool to motivate early lifestyle modification in young adults at diabetes risk: The Baependi Heart Study.Preventive medicine reports · 2020Article
- Concordance of Cardiovascular Risk Factors and Behaviors in a Multiethnic US Nationwide Cohort of Married Couples and Domestic Partners.JAMA network open · 2020Article
- Sex differences in the association between spousal metabolic risk factors with incidence of type 2 diabetes: a longitudinal study of the Iranian population.Biology of sex differences · 2019Article
- Spousal cardiometabolic risk factors and incidence of type 2 diabetes: a prospective analysis from the English Longitudinal Study of Ageing.Diabetologia · 2018Article
- Converse well-being of locked-in patients and caregivers.Annals of neurology · 2017Article
- Capsule Commentary on Raghavan et al., Incident Type 2 Diabetes Risk is Influenced by Obesity and Diabetes in Social Contacts: A Social Network Analysis.Journal of general internal medicine · 2016Article
- Triglyceride glucose-waist circumference, a novel and effective predictor of diabetes in first-degree relatives of type 2 diabetes patients: cross-sectional and prospective cohort study.Journal of translational medicine · 2016Article
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7 authors at 4 institutions in 1 country.
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Abstract
backgroundObesity and diabetes family history are the two strongest risk factors for type 2 diabetes (T2D). Prior work shows that an individual's obesity risk is associated with obesity in social contacts, but whether T2D risk follows similar patterns is unknown.
objectiveWe aimed to estimate the relationship between obesity or diabetes in an individual's social contacts and his/her T2D risk. We hypothesized that obesity and diabetes in social contacts would increase an individual's T2D risk.
designThis was a retrospective analysis of the community-based Framingham Offspring Study (FOS).
participantsFOS participants with T2D status, height and weight, and at least one social contact were eligible for this study (n = 4797 at Exam 1). Participants' interpersonal ties, cardiometabolic and demographic variables were available at eight exams from 1971 to 2008, and a T2D additive polygenic risk score was measured at the fifth exam. MAIN MEASURES: Primary exposures were T2D (fasting glucose ≥ 7 mmol/L or taking diabetes medications) and obesity status (BMI ≥ 30 kg/m(2)) of social contacts at a prior exam. Primary outcome was incident T2D in participants. KEY
resultsIncident T2D was associated with having a social contact with diabetes (OR 1.32, p = 0.004) or with obesity (OR 1.21, p = 0.004). In stratified analyses, incident T2D was associated with diabetes in siblings (OR 1.64, p = 0.001) and obesity in spouses (OR 1.54, p = 0.0004). The associations between diabetes and obesity in social contacts and an individual's incident diabetes risk were stronger in individuals with a high diabetes genetic risk score.
conclusionsT2D and obesity in social contacts, particularly siblings and spouses, were associated with an individual's risk of incident diabetes even after accounting for parental T2D history. Assessing risk factors in an individual's siblings and spouses can inform T2D risk; furthermore, social network based lifestyle interventions involving spouses and siblings might be a novel T2D prevention approach.
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