ReviewCritical care (London, England)2016
Regulation of the cerebral circulation: bedside assessment and clinical implications.
Review in Critical care (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 97 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multimodal Monitoring of Cerebral Autoregulation After Pediatric Brain Injury
Cerebral Autoregulation and Severe Coronavirus Disease 19 [CA-COVID]: a Single-center Physiological Study
Who cites it
97 citing papers in PubMed, 2 syntheses or guidelines pooled it, 201 citations in OpenAlex.
- Monitoring of Cerebral Blood Flow Autoregulation after Cardiac Arrest.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Evaluation of the correlation between cerebral hemodynamics and blood pressure by comparative analysis of variation in cerebral blood flow in hypertensive versus normotensive individuals: A systematic review and meta-analysis.Biomolecules & biomedicine · 2024Pooled it
- Neurological and respiratory effects of lung protective ventilation in acute brain injury patients without lung injury: brain vent, a single centre randomized interventional study.Critical care (London, England) · 2023Trial
- Association of deranged cerebrovascular reactivity with brain injury following cardiac arrest: a post-hoc analysis of the COMACARE trial.Critical care (London, England) · 2021Trial
- Effects of dobutamine and phenylephrine on cerebral perfusion in patients undergoing cerebral bypass surgery: a randomised crossover trial.British journal of anaesthesia · 2020Trial
- Toward comprehensive multimodal neuromonitoring of surrogates of cerebral autoregulation in traumatic brain injury: insights from a hyperventilation protocol.Neurophotonics · 2026Article
- Effect of body position on cerebral perfusion: a comparison of supine and seated positions assessed using conventional and upright CT perfusion.European radiology experimental · 2026Observational
- Interpolation and Imputation Strategies for Missing Segments in Continuous Pressure-Flow Cerebral Bio-Signals: A Systematic Scoping Review.Sensors (Basel, Switzerland) · 2026Article
- Quantification of the cerebral pressure-flow relationship directional sensitivity: Reliability of shorter repeated squat-stand durations.Experimental physiology · 2026Article
- Cerebrospinal fluid volume: the overlooked determinant in brain and spinal stroke.Annals of medicine and surgery (2012) · 2025Article
- Correlation between carotid Doppler ultrasound-derived parameters and cardiac output measurements: a systematic review and meta-analysis.Quantitative imaging in medicine and surgery · 2025Article
- Cervical Hyperextension Causes Acute Cerebral Congestion in Non-Anesthetized Healthy Adults: An Observational Self-Controlled Design Study.Medicina (Kaunas, Lithuania) · 2025Observational
- Early Positive Fluid Balance Associates with Increased Mortality in Neurological Critically Ill Patients: A 10-Year Cohort Study.Journal of clinical medicine · 2025Article
- Impaired Cerebral Autoregulation in Children.Pediatric neurology · 2025Review
- Latent class growth analysis of dynamic PaCoScientific reports · 2025Article
- Effect of extended intravenous diclofenac infusions on brain tissue oxygenation in patients with acute brain injury.Intensive care medicine experimental · 2025Article
- Impact of mild hypo- and hyperventilation on cerebral oxygen supply during general anesthesia.Perioperative medicine (London, England) · 2025Article
- Vascularization, Innervation, and Inflammation: Pathways Connecting the Heart-Brain Axis and Implications in a Clinical Setting.Biomedicines · 2025Review
- Individualized autoregulation-guided arterial blood pressure management in neurocritical care.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Cerebrovascular Autoregulation-Based Optimal Mean Arterial Pressure During Prostate Surgery - A Secondary Analysis of a Prospective Cohort Study.Therapeutics and clinical risk management · 2025Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regulation of the cerebral circulation relies on the complex interplay between cardiovascular, respiratory, and neural physiology. In health, these physiologic systems act to maintain an adequate cerebral blood flow (CBF) through modulation of hydrodynamic parameters; the resistance of cerebral vessels, and the arterial, intracranial, and venous pressures. In critical illness, however, one or more of these parameters can be compromised, raising the possibility of disturbed CBF regulation and its pathophysiologic sequelae. Rigorous assessment of the cerebral circulation requires not only measuring CBF and its hydrodynamic determinants but also assessing the stability of CBF in response to changes in arterial pressure (cerebral autoregulation), the reactivity of CBF to a vasodilator (carbon dioxide reactivity, for example), and the dynamic regulation of arterial pressure (baroreceptor sensitivity). Ideally, cerebral circulation monitors in critical care should be continuous, physically robust, allow for both regional and global CBF assessment, and be conducive to application at the bedside. Regulation of the cerebral circulation is impaired not only in primary neurologic conditions that affect the vasculature such as subarachnoid haemorrhage and stroke, but also in conditions that affect the regulation of intracranial pressure (such as traumatic brain injury and hydrocephalus) or arterial blood pressure (sepsis or cardiac dysfunction). Importantly, this impairment is often associated with poor patient outcome. At present, assessment of the cerebral circulation is primarily used as a research tool to elucidate pathophysiology or prognosis. However, when combined with other physiologic signals and online analytical techniques, cerebral circulation monitoring has the appealing potential to not only prognosticate patients, but also direct critical care management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.